Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q.
DNA damage repair
DNA deamination
deoxyinosine
deoxyuridine
endonuclease
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 03 2021
09 03 2021
Historique:
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
17
8
2021
Statut:
ppublish
Résumé
Spontaneous deamination of DNA cytosine and adenine into uracil and hypoxanthine, respectively, causes C to T and A to G transition mutations if left unrepaired. Endonuclease Q (EndoQ) initiates the repair of these premutagenic DNA lesions in prokaryotes by cleaving the phosphodiester backbone 5' of either uracil or hypoxanthine bases or an apurinic/apyrimidinic (AP) lesion generated by the excision of these damaged bases. To understand how EndoQ achieves selectivity toward these structurally diverse substrates without cleaving undamaged DNA, we determined the crystal structures of
Identifiants
pubmed: 33658373
pii: 2021120118
doi: 10.1073/pnas.2021120118
pmc: PMC7958190
pii:
doi:
Substances chimiques
Archaeal Proteins
0
DNA, Archaeal
0
Endonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P01 CA234228
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118047
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR029205
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Déclaration de conflit d'intérêts
Competing interest statement: D.A.H. and R.S.H. are cofounders, shareholders, and consultants of ApoGen Biotechnologies Inc.
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