Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans.

Animals Antioxidants / metabolism Caenorhabditis elegans / drug effects Caenorhabditis elegans Proteins / genetics Cysteine / metabolism Hydrogen Peroxide / pharmacology MAP Kinase Kinase 4 / metabolism Mitogen-Activated Protein Kinases / genetics Mutation Oxidation-Reduction Proteomics / methods Signal Transduction Transcription Factors / metabolism p38 Mitogen-Activated Protein Kinases / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
03 03 2021
Historique:
received: 23 07 2020
accepted: 08 02 2021
entrez: 4 3 2021
pubmed: 5 3 2021
medline: 19 3 2021
Statut: epublish

Résumé

Post-translational changes in the redox state of cysteine residues can rapidly and reversibly alter protein functions, thereby modulating biological processes. The nematode C. elegans is an ideal model organism for studying cysteine-mediated redox signaling at a network level. Here we present a comprehensive, quantitative, and site-specific profile of the intrinsic reactivity of the cysteinome in wild-type C. elegans. We also describe a global characterization of the C. elegans redoxome in which we measured changes in three major cysteine redox forms after H

Identifiants

DOI: 10.1038/s41467-021-21686-3 PMID: 33658510 PMC: PMC7930113
pubmed: 33658510
doi: 10.1038/s41467-021-21686-3
pii: 10.1038/s41467-021-21686-3
pmc: PMC7930113
doi:

Substances chimiques

Antioxidants 0
Caenorhabditis elegans Proteins 0
DAF-19 protein, C elegans 0
Transcription Factors 0
Hydrogen Peroxide BBX060AN9V
Mitogen-Activated Protein Kinases EC 2.7.11.24
Pmk-1 protein, C elegans EC 2.7.11.24
p38 Mitogen-Activated Protein Kinases EC 2.7.11.24
MAP Kinase Kinase 4 EC 2.7.12.2
sek-1 protein, C elegans EC 2.7.12.2
Cysteine K848JZ4886

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1415

Subventions

Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227849
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122610
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM102187
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM087638
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States

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Auteurs

Jin Meng (J)

Research Division, Joslin Diabetes Center, Boston, MA, USA.
Department of Genetics, Harvard Medical School, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.
ORCID: 0000-0002-1347-9730

Ling Fu (L)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Innovation Institute of Medical School, Medical College, Qingdao University, Qingdao, China.

Keke Liu (K)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.

Caiping Tian (C)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
School of Medicine, Tsinghua University, Beijing, China.

Ziyun Wu (Z)

Research Division, Joslin Diabetes Center, Boston, MA, USA.
Department of Genetics, Harvard Medical School, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.

Youngeun Jung (Y)

Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.

Renan B Ferreira (RB)

Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
ORCID: 0000-0001-5205-659X

Kate S Carroll (KS)

Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
ORCID: 0000-0002-7624-9617

T Keith Blackwell (TK)

Research Division, Joslin Diabetes Center, Boston, MA, USA. keith.blackwell@joslin.harvard.edu.
Department of Genetics, Harvard Medical School, Boston, MA, USA. keith.blackwell@joslin.harvard.edu.
Harvard Stem Cell Institute, Cambridge, MA, USA. keith.blackwell@joslin.harvard.edu.

Jing Yang (J)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. yangjing54@hotmail.com.
Innovation Institute of Medical School, Medical College, Qingdao University, Qingdao, China. yangjing54@hotmail.com.
ORCID: 0000-0001-8486-273X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Mitogen-Activated Protein Kinase Kinases › MAP Kinase Kinase 4 › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Global profiling of distinct cysteine redox...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › p38 Mitogen-Activated Protein Kinases › Global profiling of distinct cysteine redox...