MicroRNA-2187 Modulates the NF-κB and IRF3 Pathway in Teleost Fish by Targeting TRAF6.
Animals
Base Sequence
Cells, Cultured
Cytokines
/ genetics
Fish Diseases
/ genetics
Fish Proteins
/ genetics
Gene Expression Regulation
/ immunology
Host-Pathogen Interactions
/ immunology
Immunity, Innate
/ genetics
Interferon Regulatory Factor-3
/ genetics
MicroRNAs
/ genetics
NF-kappa B
/ genetics
Perciformes
/ genetics
Rhabdoviridae
/ immunology
Sequence Homology, Nucleic Acid
Signal Transduction
/ genetics
TNF Receptor-Associated Factor 6
/ genetics
Vibrio
/ immunology
TRAF6
fish
immune response
miR-2187
negative regulation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
12
2020
accepted:
22
01
2021
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
28
9
2021
Statut:
epublish
Résumé
The innate immune organs and cells detect the invasion of pathogenic microorganisms, which trigger the innate immune response. A proper immune response can protect the organisms from pathogen invasion. However, excessive immunity can destroy immune homeostasis, leading to uncontrolled inflammation or pathogen transmission. Evidence shows that the miRNA-mediated immune regulatory network in mammals has had a significant impact, but the antibacterial and antiviral responses involved in miRNAs need to be further studied in lower vertebrates. Here, we report that miR-2187 as a negative regulator playing a critical role in the antiviral and antibacterial response of miiuy croaker. We find that pathogens such as
Identifiants
pubmed: 33659012
doi: 10.3389/fimmu.2021.647202
pmc: PMC7917119
doi:
Substances chimiques
Cytokines
0
Fish Proteins
0
Interferon Regulatory Factor-3
0
MicroRNAs
0
NF-kappa B
0
TNF Receptor-Associated Factor 6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
647202Informations de copyright
Copyright © 2021 Gao, Chang, Sun and Xu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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