A 3' tRNA-derived fragment produced by tRNA
chronic lymphocytic leukemia
molecular biomarker
tRF-3
tRNA fragment
unfavorable prognosis
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
01
03
2021
received:
23
11
2020
accepted:
02
03
2021
pubmed:
5
3
2021
medline:
30
11
2021
entrez:
4
3
2021
Statut:
ppublish
Résumé
3' tRNA-derived fragments (3' tRFs) are important epigenetic regulators in normal and pathological conditions. In this study, we aimed to explore the potential value of a 3' tRF as a prognostic and/or screening biomarker for B-cell chronic lymphocytic leukemia (B-CLL). Publicly available next-generation sequencing data from 20 B-CLL cases were analyzed, followed by prediction of targets of the most abundantly and ubiquitously expressed 3' tRFs, leading to selection of tRF-Leu High tRF-Leu Our approach revealed the independent prognostic value of a particular 3' tRF, derived from tRNA
Substances chimiques
Biomarkers, Tumor
0
RNA, Neoplasm
0
RNA, Transfer, Leu
0
Banques de données
GENBANK
['MK671733.1']
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
821-830Subventions
Organisme : Bodossaki Foundation
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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