Modified Glasgow Prognostic Score predicts survival among advanced non-small cell lung carcinoma patients treated with anti-PD1 agents.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
/ drug therapy
Cigarette Smoking
/ epidemiology
Comorbidity
Female
Humans
Immune Checkpoint Inhibitors
/ adverse effects
Inflammation Mediators
/ metabolism
Lung Neoplasms
/ drug therapy
Lymphocytes
/ cytology
Male
Middle Aged
Neoplasm Metastasis
Neutrophils
/ cytology
Prognosis
Severity of Illness Index
Journal
Anti-cancer drugs
ISSN: 1473-5741
Titre abrégé: Anticancer Drugs
Pays: England
ID NLM: 9100823
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
pubmed:
5
3
2021
medline:
17
11
2021
entrez:
4
3
2021
Statut:
ppublish
Résumé
Immune checkpoint inhibitors were approved for advanced nonsmall cell lung cancer (NSCLC) treatment. Despite improved survival, not all patients benefit from these agents. Here, the prognostic impact of pretreatment modified Glasgow Prognostic Score (mGPS) and neutrophil-to-lymphocyte ratio (NLR) was assessed. From 77 patients included, 83.2% received at least one prior systemic therapy. Immune-related adverse events (irAE) occurred in 20 patients. A lower mGPS was associated with higher median overall survival (OS), and a lower Eastern Cooperative Oncology Group (ECOG), irAE and fewer metastatic sites with better survival. A trend towards greater OS and progression-free survival (PFS) was stated among patients with NLR <5. mGPS 0 was associated with better survival; ≥3 metastatic sites with worse PFS and OS; ECOG >2 with worse OS and irAE with better survival. Pretreatment mGPS seems to be useful for predicting survival among advanced NSCLC patients treated with anti-programmed cell death 1 drugs, with ECOG performance status, irAE occurrence, and number of metastatic sites acting as survival predictors.
Identifiants
pubmed: 33661189
doi: 10.1097/CAD.0000000000001060
pii: 00001813-202106000-00010
doi:
Substances chimiques
Biomarkers, Tumor
0
Immune Checkpoint Inhibitors
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-574Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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