Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
10
2020
accepted:
14
02
2021
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
17
3
2021
Statut:
epublish
Résumé
COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twenty-one substitutions that have frequencies greater than 3% of viral population were identified. Analysis of these substitutions indicated that P1427I (ORF1b), Y1464C (ORF1b), and Q57H (ORF3a) might affect functions of the corresponding SARS-CoV-2 encoded proteins. Additionally, we found the evidence of positive selection on the ORF3a and codon 614 of Spike protein, suggesting the viral components responsible for host entry and activation of inflammation response were targeted by host immune responses. The study showed genomic variation and evolution of SARS-CoV-2 in a Canadian population. These information may help develop preventive strategies and be used for further study of SARS-CoV-2 pathogenesis and therapeutics development.
Identifiants
pubmed: 33662015
doi: 10.1371/journal.pone.0247799
pii: PONE-D-20-31699
pmc: PMC7932534
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
Viral Proteins
0
spike glycoprotein, SARS-CoV
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0247799Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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