Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder.
Anhedonia
Functional connectivity
Major depressive disorder
Nucleus accumbens
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
01
2020
revised:
10
02
2021
accepted:
11
02
2021
pubmed:
5
3
2021
medline:
31
7
2021
entrez:
4
3
2021
Statut:
ppublish
Résumé
The nucleus accumbens (NAc) is an important region in reward circuit that has been linked with anhedonia, which is a characteristic symptom of major depressive disorder (MDD). However, the relationship between the functional connectivity of the NAc subregions and anhedonia in MDD patients remains unclear. We acquired resting-state functional magnetic resonance imaging (fMRI) scans from fifty-one subjects (23 MDD patients and 28 healthy controls). We assessed subjects' trait anhedonia with the Temporal Experience of Pleasure Scale (TEPS). Seed-based resting-state functional connectivity (rsFC) was conducted for each of the NAc subregions (bilateral core-like and shell-like subdivisions) separately to identify regions whose rsFCs with the NAc subregions were altered in the MDD patients and regions whose rsFCs with the NAc subregions showed different correlates with anhedonia between the MDD patients and the healthy controls. Compared with the health controls, the MDD patients showed decreased rsFCs of the right NAc core-like subdivision with the left mid-anterior orbital prefrontal cortex and the right inferior parietal lobe as well as decreased rsFC of the left NAc core-like subdivision with the right middle frontal gyrus. Moreover, the severity of anhedonia by the group interaction was significant for the rsFC of the right NAc shell-like subdivision with the subgenual/pregenual anterior cingulate cortex and the rsFC of the right NAc core-like subdivision with the precuneus. We found that the neural correlates of anhedonia indicated by the rsFCs of the NAc subregions were modulated by depression. The modulation effect was regionally-dependent. These findings enrich our understanding of the neural basis of anhedonia in MDD.
Sections du résumé
BACKGROUND
The nucleus accumbens (NAc) is an important region in reward circuit that has been linked with anhedonia, which is a characteristic symptom of major depressive disorder (MDD). However, the relationship between the functional connectivity of the NAc subregions and anhedonia in MDD patients remains unclear.
METHODS
We acquired resting-state functional magnetic resonance imaging (fMRI) scans from fifty-one subjects (23 MDD patients and 28 healthy controls). We assessed subjects' trait anhedonia with the Temporal Experience of Pleasure Scale (TEPS). Seed-based resting-state functional connectivity (rsFC) was conducted for each of the NAc subregions (bilateral core-like and shell-like subdivisions) separately to identify regions whose rsFCs with the NAc subregions were altered in the MDD patients and regions whose rsFCs with the NAc subregions showed different correlates with anhedonia between the MDD patients and the healthy controls.
RESULTS
Compared with the health controls, the MDD patients showed decreased rsFCs of the right NAc core-like subdivision with the left mid-anterior orbital prefrontal cortex and the right inferior parietal lobe as well as decreased rsFC of the left NAc core-like subdivision with the right middle frontal gyrus. Moreover, the severity of anhedonia by the group interaction was significant for the rsFC of the right NAc shell-like subdivision with the subgenual/pregenual anterior cingulate cortex and the rsFC of the right NAc core-like subdivision with the precuneus.
CONCLUSIONS
We found that the neural correlates of anhedonia indicated by the rsFCs of the NAc subregions were modulated by depression. The modulation effect was regionally-dependent. These findings enrich our understanding of the neural basis of anhedonia in MDD.
Identifiants
pubmed: 33662708
pii: S2213-1582(21)00043-7
doi: 10.1016/j.nicl.2021.102599
pmc: PMC7930634
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102599Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.