Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics.
A549 Cells
Acute Kidney Injury
/ prevention & control
Animals
Antineoplastic Agents
/ adverse effects
Catalytic Domain
Cell Line, Tumor
Cerium
/ chemistry
Female
Hep G2 Cells
Humans
Kelch-Like ECH-Associated Protein 1
/ metabolism
Kidney Tubules
/ pathology
Mice
Mice, Inbred BALB C
Mice, Nude
NF-E2-Related Factor 2
/ genetics
Nanoparticles
/ chemistry
Neoplasms
/ drug therapy
Oxidation-Reduction
Oxidative Stress
/ drug effects
RNA Interference
RNA, Small Interfering
/ genetics
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Tumor Microenvironment
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 03 2021
04 03 2021
Historique:
received:
24
02
2020
accepted:
01
02
2021
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
18
3
2021
Statut:
epublish
Résumé
Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It is correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management is a practical strategy that can reduce the risk of chemotherapy-related AKI, but at the cost of chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) that can prevent chemotherapy-induced AKI without interference with chemotherapeutic agents. Specifically, in the renal cortex, CNPs exhibit catalytic activity that decomposes hydrogen peroxide, and subsequently regulate the ROS-involved genes by activating the Nrf2/Keap1 signaling pathway. These restore the redox homeostasis for the protection of kidney tubules. Under an acidic tumor microenvironment, CNPs become inert due to the excessive H
Identifiants
pubmed: 33664241
doi: 10.1038/s41467-021-21714-2
pii: 10.1038/s41467-021-21714-2
pmc: PMC7933428
doi:
Substances chimiques
Antineoplastic Agents
0
KEAP1 protein, human
0
Kelch-Like ECH-Associated Protein 1
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
RNA, Small Interfering
0
Reactive Oxygen Species
0
Cerium
30K4522N6T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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