The food additive EDTA aggravates colitis and colon carcinogenesis in mouse models.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 03 2021
04 03 2021
Historique:
received:
24
11
2020
accepted:
04
02
2021
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Inflammatory bowel disease is a group of conditions with rising incidence caused by genetic and environmental factors including diet. The chelator ethylenediaminetetraacetate (EDTA) is widely used by the food and pharmaceutical industry among numerous other applications, leading to a considerable environmental exposure. Numerous safety studies in healthy animals have revealed no relevant toxicity by EDTA. Here we show that, in the presence of intestinal inflammation, EDTA is surprisingly capable of massively exacerbating inflammation and even inducing colorectal carcinogenesis at doses that are presumed to be safe. This toxicity is evident in two biologically different mouse models of inflammatory bowel disease, the AOM/DSS and the IL10
Identifiants
pubmed: 33664327
doi: 10.1038/s41598-021-84571-5
pii: 10.1038/s41598-021-84571-5
pmc: PMC7933154
doi:
Substances chimiques
Food Additives
0
IL10 protein, mouse
0
Interleukin-10
130068-27-8
Edetic Acid
9G34HU7RV0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5188Références
Mucosal Immunol. 2018 Nov;11(6):1630-1639
pubmed: 30115995
Dig Dis Sci. 2005 Apr;50(4):696-707
pubmed: 15844705
Gut. 2011 Mar;60(3):325-33
pubmed: 21076126
Bioinformatics. 2012 Jul 15;28(14):1823-9
pubmed: 22556368
Cancer Metastasis Rev. 2015 Dec;34(4):593-609
pubmed: 25634251
Aliment Pharmacol Ther. 2005 Dec;22(11-12):1097-105
pubmed: 16305723
PeerJ. 2017 Jan 11;5:e2836
pubmed: 28097056
FEBS Lett. 2014 Nov 17;588(22):4158-66
pubmed: 24842610
Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G774-83
pubmed: 20224006
Food Chem Toxicol. 2000 Jan;38(1):99-111
pubmed: 10685019
Gastroenterology. 2017 May;152(6):1419-1433.e5
pubmed: 28126350
Lab Invest. 1993 Aug;69(2):238-49
pubmed: 8350599
Clin Exp Immunol. 1999 Sep;117(3):462-8
pubmed: 10469048
Adv Wound Care (New Rochelle). 2015 Jul 1;4(7):415-421
pubmed: 26155384
Cell Rep. 2017 Apr 25;19(4):733-745
pubmed: 28445725
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Inflamm Bowel Dis. 2008 Mar;14(3):374-82
pubmed: 17932967
Cell Mol Gastroenterol Hepatol. 2020;9(4):641-659
pubmed: 31874254
Inflamm Bowel Dis. 2015 Mar;21(3):579-88
pubmed: 25545376
Carcinogenesis. 2015 Nov;36(11):1388-96
pubmed: 26320104
Oncotarget. 2018 Mar 30;9(24):17066-17077
pubmed: 29682205
Mediators Inflamm. 2015;2015:628157
pubmed: 26582965
Sci Rep. 2019 Feb 26;9(1):2842
pubmed: 30809073
FASEB J. 2008 Mar;22(3):659-61
pubmed: 17942826
Eur J Cell Biol. 2005 Mar;84(2-3):225-33
pubmed: 15819403
Aliment Pharmacol Ther. 2001 Dec;15(12):1989-99
pubmed: 11736731
Toxicol Appl Pharmacol. 1981 Dec;61(3):423-8
pubmed: 6800065
Nat Commun. 2020 Apr 14;11(1):1775
pubmed: 32286299
Gastroenterology. 1990 Mar;98(3):694-702
pubmed: 1688816
Aliment Pharmacol Ther. 2018 Jan;47(1):67-77
pubmed: 29052237
Gut. 2017 Oct;66(10):1748-1760
pubmed: 27371534
Cell. 1993 Oct 22;75(2):263-74
pubmed: 8402911
J Biol Chem. 1953 Aug;203(2):1045-53
pubmed: 13084675
Scand J Gastroenterol. 2005 Sep;40(9):1058-65
pubmed: 16165718
Inflamm Bowel Dis. 2017 May;23(5):753-766
pubmed: 28368910
Int J Clin Exp Pathol. 2014 Jul 15;7(8):4557-76
pubmed: 25197329
PLoS One. 2013 Nov 06;8(11):e78850
pubmed: 24223168
J Clin Gastroenterol. 2006 May-Jun;40(5):391-7
pubmed: 16721219
Cancer Sci. 2003 Nov;94(11):965-73
pubmed: 14611673
Am J Gastroenterol. 2010 Nov;105(11):2420-8
pubmed: 20648002
Mol Cancer Res. 2018 Apr;16(4):634-642
pubmed: 29378905
Gastroenterology. 2015 May;148(6):1087-106
pubmed: 25597840
Dig Dis Sci. 2002 Jun;47(6):1266-78
pubmed: 12064801
Lab Anim. 1981 Jan;15(1):57-9
pubmed: 7022018
J Dig Dis. 2019 Aug;20(8):401-408
pubmed: 31070838
Nature. 2015 Mar 5;519(7541):92-6
pubmed: 25731162
Dig Dis. 2016;34 Suppl 1:48-55
pubmed: 27548430
Gut. 2017 Jul;66(7):1216-1224
pubmed: 26848183
Toxicol Appl Pharmacol. 1963 Mar;5:142-62
pubmed: 13940503
World Health Organ Tech Rep Ser. 1974;539:1-40
pubmed: 4205977
J Nutr. 2004 Sep;134(9):2251-5
pubmed: 15333712
Inflamm Bowel Dis. 2005 Dec;11(12):1060-9
pubmed: 16306768