Cytoplasmic DNA sensing by KU complex in aged CD4

Aging / immunology Animals Autoimmune Diseases / immunology CD4-Positive T-Lymphocytes / immunology Cell Line Cell Line, Tumor Cell Nucleus / immunology Cell Proliferation / physiology Cytoplasm / immunology DNA / immunology DNA Repair / immunology DNA-Activated Protein Kinase / immunology HEK293 Cells Humans Inflammation / immunology Jurkat Cells Lymphocyte Activation / immunology Mice Mice, Inbred C57BL U937 Cells
CD4(+) T cells DNA sensing KU complex ZAK aging autoimmunity

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
13 04 2021
Historique:
received: 08 08 2020
revised: 19 09 2020
accepted: 08 02 2021
pubmed: 6 3 2021
medline: 15 9 2021
entrez: 5 3 2021
Statut: ppublish

Résumé

Aging is associated with DNA accumulation and increased homeostatic proliferation of circulating T cells. Although these attributes are associated with aging-related autoimmunity, their direct contributions remain unclear. Conventionally, KU complex, the regulatory subunit of DNA-dependent protein kinase (DNA-PK), together with the catalytic subunit of DNA-PK (DNA-PKcs), mediates DNA damage repair in the nucleus. Here, we found KU complex abundantly expressed in the cytoplasm, where it recognized accumulated cytoplasmic DNA in aged human and mouse CD4

Identifiants

DOI: 10.1016/j.immuni.2021.02.003 PMID: 33667382
pubmed: 33667382
pii: S1074-7613(21)00069-8
doi: 10.1016/j.immuni.2021.02.003
pii:
doi:

Substances chimiques

DNA 9007-49-2
DNA-Activated Protein Kinase EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

632-647.e9

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Yan Wang (Y)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Zunyun Fu (Z)

Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201203, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Xutong Li (X)

Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201203, China.

Yinming Liang (Y)

School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China.

Siyu Pei (S)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Shumeng Hao (S)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Qingchen Zhu (Q)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Tao Yu (T)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Yifei Pei (Y)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Jia Yuan (J)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Jialin Ye (J)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Jiemeng Fu (J)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Jing Xu (J)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Jin Hong (J)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Ruirui Yang (R)

Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201203, China; Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China.

Hui Hou (H)

Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201203, China.

Xinfang Huang (X)

Department of Rheumatology, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, China.

Chao Peng (C)

National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai 201210, China.

Mingyue Zheng (M)

Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: myzheng@simm.ac.cn.

Yichuan Xiao (Y)

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: ycxiao@sibs.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Eucaryotes › Animaux › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › DNA-activated protein kinase › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Cellules Jurkat › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cytoplasmic DNA sensing by KU complex in aged CD4
questionsmedicales.fr › Cellules › Cellules myéloïdes › Cellules U937 › Cytoplasmic DNA sensing by KU complex in aged CD4