The Multi-Targeting Ligand ST-2223 with Histamine H
Animals
Anxiety
/ drug therapy
Autism Spectrum Disorder
/ drug therapy
Brain
/ drug effects
Disease Models, Animal
Dopamine D2 Receptor Antagonists
/ administration & dosage
Grooming
/ drug effects
HEK293 Cells
Histamine H3 Antagonists
/ administration & dosage
Humans
Ligands
Locomotion
/ drug effects
Male
Mice
Mice, Inbred C57BL
Oxidative Stress
/ drug effects
Receptors, Dopamine D2
/ metabolism
Receptors, Dopamine D3
/ antagonists & inhibitors
Receptors, Histamine H3
/ metabolism
BTBR mice
anxiety
autistic spectrum disorder
dopamine D2/D3R antagonist
histamine H3 receptor antagonist
oxidative stress
repetitive and restricted behavior
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Feb 2021
16 Feb 2021
Historique:
received:
20
01
2021
revised:
08
02
2021
accepted:
09
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
27
4
2021
Statut:
epublish
Résumé
Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current pharmacotherapies in treating repetitive behaviors, the present study determined the effects of acute systemic treatment of the novel multi-targeting ligand ST-2223, with incorporated histamine H
Identifiants
pubmed: 33669336
pii: ijms22041947
doi: 10.3390/ijms22041947
pmc: PMC7920280
pii:
doi:
Substances chimiques
Dopamine D2 Receptor Antagonists
0
Histamine H3 Antagonists
0
Ligands
0
Receptors, Dopamine D2
0
Receptors, Dopamine D3
0
Receptors, Histamine H3
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : United Arab Emirates University
ID : 31R233 and 31R244
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