Cardioprotective Effects of a Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, in Dahl Salt-Sensitive Hypertensive Rats.

Animals Cardiotonic Agents / pharmacology Electrocardiography Fibrosis Hypertension / diagnostic imaging Inflammation / complications Male Mineralocorticoid Receptor Antagonists / therapeutic use Pyrroles / pharmacology Rats, Inbred Dahl Receptors, Mineralocorticoid / metabolism Sodium Chloride, Dietary Sulfones / pharmacology Survival Analysis Ventricular Remodeling / drug effects
cardiac function esaxerenone nonsteroidal mineralocorticoid receptor blocker salt-sensitive hypertension

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Feb 2021
Historique:
received: 07 02 2021
revised: 09 02 2021
accepted: 17 02 2021
entrez: 6 3 2021
pubmed: 7 3 2021
medline: 16 4 2021
Statut: epublish

Résumé

We investigated the effects of esaxerenone, a novel, nonsteroidal, and selective mineralocorticoid receptor blocker, on cardiac function in Dahl salt-sensitive (DSS) rats. We provided 6-week-old DSS rats a high-salt diet (HSD, 8% NaCl). Following six weeks of HSD feeding (establishment of cardiac hypertrophy), we divided the animals into the following two groups: HSD or HSD + esaxerenone (0.001%,

Identifiants

DOI: 10.3390/ijms22042069 PMID: 33669786 PMC: PMC7922950
pubmed: 33669786
pii: ijms22042069
doi: 10.3390/ijms22042069
pmc: PMC7922950
pii:
doi:

Substances chimiques

Cardiotonic Agents 0
Mineralocorticoid Receptor Antagonists 0
Pyrroles 0
Receptors, Mineralocorticoid 0
Sodium Chloride, Dietary 0
Sulfones 0
esaxerenone N62TGJ04A1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : This study was in part a collaborative study with Daiichi-Sankyo Co., Ltd (to A.N.). This study was also supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan (18H03191 to A.N.) and from the Salt
ID : N/A

Références

Congest Heart Fail. 2005 Jan-Feb;11(1):12-6
pubmed: 15722665
Eur J Pharmacol. 2015 Aug 15;761:226-34
pubmed: 26073023
N Engl J Med. 2003 Apr 3;348(14):1309-21
pubmed: 12668699
Hypertens Res. 2019 Jun;42(6):769-778
pubmed: 30587856
Circulation. 2007 Jul 17;116(3):268-75
pubmed: 17606839
Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R946-54
pubmed: 17023667
Heart Fail Rev. 2005 Jan;10(1):71-8
pubmed: 15947894
Curr Opin Hematol. 2000 May;7(3):178-82
pubmed: 10786656
Hypertension. 2011 Apr;57(4):746-54
pubmed: 21321305
BMJ. 2009 Nov 24;339:b4567
pubmed: 19934192
N Engl J Med. 2011 Jan 6;364(1):11-21
pubmed: 21073363
Circulation. 2007 Mar 20;115(11):1398-407
pubmed: 17353445
Hypertension. 2012 Feb;59(2):500-6
pubmed: 22232135
ChemMedChem. 2012 Aug;7(8):1385-403
pubmed: 22791416
J Cardiovasc Pharmacol. 2014 Jul;64(1):69-78
pubmed: 24621652
Hypertension. 2008 Jan;51(1):134-40
pubmed: 18039983
Circulation. 2005 Jun 14;111(23):3025-33
pubmed: 15939817
Hypertens Res. 2019 Dec;42(12):1932-1941
pubmed: 31554937
N Engl J Med. 1999 Sep 2;341(10):709-17
pubmed: 10471456
Hypertens Res. 2019 Mar;42(3):293-300
pubmed: 30523293
Curr Pharm Des. 2018;24(46):5537-5541
pubmed: 30799782
Hypertens Res. 2019 Oct;42(10):1572-1581
pubmed: 31239535
Circulation. 2011 Feb 1;123(4):400-8
pubmed: 21242479
J Mol Cell Cardiol. 2018 Aug;121:124-133
pubmed: 29981797
Clin J Am Soc Nephrol. 2019 Aug 7;14(8):1161-1172
pubmed: 31248950
Circ J. 2008;72 Suppl A:A31-7
pubmed: 18772530
Hypertension. 2012 Dec;60(6):1443-50
pubmed: 23108646
Hypertension. 2016 Jan;67(1):99-106
pubmed: 26527051
Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2035-43
pubmed: 21441311
Biochem Pharmacol. 2019 Oct;168:173-183
pubmed: 31283930
Am J Pathol. 2004 Feb;164(2):449-56
pubmed: 14742251
J Hum Hypertens. 2021 Feb;35(2):148-156
pubmed: 32661269
J Cell Biol. 1993 Jul;122(1):103-11
pubmed: 8314838
Hypertension. 2020 Jan;75(1):51-58
pubmed: 31786983
Int J Biol Sci. 2018 Sep 7;14(12):1645-1657
pubmed: 30416379
Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1675-86
pubmed: 22556335
J Mol Med (Berl). 2006 May;84(5):396-404
pubmed: 16604333
Hypertension. 2006 Apr;47(4):656-64
pubmed: 16505208
Hypertens Res. 2009 May;32(5):321-4
pubmed: 19300447
FEBS Lett. 2020 May;594(10):1615-1623
pubmed: 31991486
Am J Physiol. 1994 Dec;267(6 Pt 2):H2471-82
pubmed: 7810745

Auteurs

Asadur Rahman (A)

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
ORCID: 0000-0002-9172-5343

Tatsuya Sawano (T)

Division of Pharmacology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.
ORCID: 0000-0003-1713-2045

Anupoma Sen (A)

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Akram Hossain (A)

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Nourin Jahan (N)

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Hideki Kobara (H)

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
ORCID: 0000-0002-8508-827X

Tsutomu Masaki (T)

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Shinji Kosaka (S)

Department of Pharmacy, Kagawa University Hospital, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Kento Kitada (K)

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Daisuke Nakano (D)

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
ORCID: 0000-0002-7435-8465

Takeshi Imamura (T)

Division of Pharmacology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

Hiroyuki Ohsaki (H)

Department of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Suma-ku, Kobe, Hyogo 654-0142, Japan.

Akira Nishiyama (A)

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
ORCID: 0000-0001-5971-820X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Cardiotoniques › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrocardiographie › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Diurétiques › Diurétiques d'épargne potassique › Antagonistes des récepteurs des minéralocorticoïdes › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrroles › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée Dahl › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs des minéralocorticoïdes › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du sodium › Sodium alimentaire › Chlorure de sodium alimentaire › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Cardioprotective Effects of a Nonsteroidal...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Remodelage ventriculaire › Cardioprotective Effects of a Nonsteroidal...