Estrogen Receptors in Polycystic Ovary Syndrome.
estrogen
estrogen receptor
ovary
polycystic ovary syndrome
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
21 02 2021
21 02 2021
Historique:
received:
30
12
2020
revised:
17
02
2021
accepted:
18
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
27
8
2021
Statut:
epublish
Résumé
Female infertility is mainly caused by ovulation disorders, which affect female reproduction and pregnancy worldwide, with polycystic ovary syndrome (PCOS) being the most prevalent of these. PCOS is a frequent endocrine disease that is associated with abnormal function of the female sex hormone estrogen and estrogen receptors (ERs). Estrogens mediate genomic effects through ERα and ERβ in target tissues. The G-protein-coupled estrogen receptor (GPER) has recently been described as mediating the non-genomic signaling of estrogen. Changes in estrogen receptor signaling pathways affect cellular activities, such as ovulation; cell cycle phase; and cell proliferation, migration, and invasion. Over the years, some selective estrogen receptor modulators (SERMs) have made substantial strides in clinical applications for subfertility with PCOS, such as tamoxifen and clomiphene, however the role of ER in PCOS still needs to be understood. This article focuses on the recent progress in PCOS caused by the abnormal expression of estrogen and ERs in the ovaries and uterus, and the clinical application of related targeted small-molecule drugs.
Identifiants
pubmed: 33669960
pii: cells10020459
doi: 10.3390/cells10020459
pmc: PMC7924872
pii:
doi:
Substances chimiques
Estrogen Receptor Modulators
0
Receptors, Estrogen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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