Therapeutic Advances in Oncology.
Antibodies, Monoclonal
/ therapeutic use
Cell- and Tissue-Based Therapy
/ methods
Genetic Therapy
/ methods
Humans
Immunoconjugates
/ therapeutic use
Immunotherapy
/ methods
Medical Oncology
/ methods
Molecular Targeted Therapy
/ methods
Neoplasms
/ classification
Small Molecule Libraries
/ therapeutic use
breast cancer
innovation
lung cancer
multiple myeloma
oncology
therapeutic modalities
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Feb 2021
18 Feb 2021
Historique:
received:
26
01
2021
revised:
15
02
2021
accepted:
16
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
20
4
2021
Statut:
epublish
Résumé
Around 77 new oncology drugs were approved by the FDA in the past five years; however, most cancers remain untreated. Small molecules and antibodies are dominant therapeutic modalities in oncology. Antibody-drug conjugates, bispecific antibodies, peptides, cell, and gene-therapies are emerging to address the unmet patient need. Advancement in the discovery and development platforms, identification of novel targets, and emergence of new technologies have greatly expanded the treatment options for patients. Here, we provide an overview of various therapeutic modalities and the current treatment options in oncology, and an in-depth discussion of the therapeutics in the preclinical stage for the treatment of breast cancer, lung cancer, and multiple myeloma.
Identifiants
pubmed: 33670524
pii: ijms22042008
doi: 10.3390/ijms22042008
pmc: PMC7922397
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Immunoconjugates
0
Small Molecule Libraries
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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