Role of Constitutive STAR in Leydig Cells.
Animals
Base Sequence
CRISPR-Associated Protein 9
/ metabolism
CRISPR-Cas Systems
/ genetics
Diglycerides
/ metabolism
Gene Deletion
Leydig Cells
/ metabolism
Ligands
Lipid Droplets
/ metabolism
Male
Mice, Inbred C57BL
Models, Biological
Phosphoproteins
/ metabolism
Progesterone
/ metabolism
Rats, Sprague-Dawley
Receptors, GABA
/ metabolism
Signal Transduction
Steroids
/ biosynthesis
STAR
cholesterol
diacylglycerol
lipid droplets
steroidogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Feb 2021
18 Feb 2021
Historique:
received:
18
01
2021
revised:
13
02
2021
accepted:
17
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
16
4
2021
Statut:
epublish
Résumé
Leydig cells contain significant amounts of constitutively produced steroidogenic acute regulatory protein (STAR; STARD1). Hormone-induced STAR plays an essential role in inducing the transfer of cholesterol into the mitochondria for hormone-dependent steroidogenesis. STAR acts at the outer mitochondrial membrane, where it interacts with a protein complex, which includes the translocator protein (TSPO). Mutations in STAR cause lipoid congenital adrenal hyperplasia (lipoid CAH), a disorder characterized by severe defects in adrenal and gonadal steroid production; in Leydig cells, the defects are seen mainly after the onset of hormone-dependent androgen formation. The function of constitutive STAR in Leydig cells is unknown. We generated STAR knockout (KO) MA-10 mouse tumor Leydig cells and showed that STAR KO cells failed to form progesterone in response to dibutyryl-cAMP and to TSPO drug ligands, but not to 22(
Identifiants
pubmed: 33670702
pii: ijms22042021
doi: 10.3390/ijms22042021
pmc: PMC7922663
pii:
doi:
Substances chimiques
Bzrp protein, mouse
0
Diglycerides
0
Ligands
0
Phosphoproteins
0
Receptors, GABA
0
Steroids
0
steroidogenic acute regulatory protein
0
Progesterone
4G7DS2Q64Y
CRISPR-Associated Protein 9
EC 3.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Southern California
ID : N/A
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