Effects of Irregular Feeding on the Daily Fluctuations in mRNA Expression of the Neurosecretory Protein GL and Neurosecretory Protein GM Genes in the Mouse Hypothalamus.
Analysis of Variance
Animals
Anorexia
/ blood
Blood Glucose
/ metabolism
CLOCK Proteins
/ genetics
Feeding Behavior
/ physiology
Gene Expression Profiling
Gene Expression Regulation
Hypothalamus
/ metabolism
Insulin
/ blood
Lipid Metabolism
/ genetics
Male
Mice, Inbred C57BL
Nerve Tissue Proteins
/ genetics
Orexins
/ metabolism
RNA, Messenger
/ genetics
Time Factors
environmental light/dark cycle
fat accumulation
feeding restriction
food intake
neurosecretory protein GL
neurosecretory protein GM
rhythmicity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Feb 2021
20 Feb 2021
Historique:
received:
12
01
2021
revised:
15
02
2021
accepted:
18
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
15
4
2021
Statut:
epublish
Résumé
Circadian desynchrony induced by a long period of irregular feeding leads to metabolic diseases, such as obesity and diabetes mellitus. The recently identified neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM) are hypothalamic small proteins that stimulate food intake and fat accumulation in several animals. To clarify the mechanisms that evoke feeding behavior and induce energy metabolism at the appropriate times in accordance with a circadian rhythm, diurnal fluctuations in
Identifiants
pubmed: 33672695
pii: ijms22042109
doi: 10.3390/ijms22042109
pmc: PMC7924315
pii:
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
NPGM protein, mouse
0
Nerve Tissue Proteins
0
Orexins
0
RNA, Messenger
0
neurosecretory protein GL, mouse
0
CLOCK Proteins
EC 2.3.1.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP18K19743
Organisme : Japan Society for the Promotion of Science
ID : JP19H03258
Organisme : Japan Society for the Promotion of Science
ID : JP20K21760
Organisme : Japan Society for the Promotion of Science
ID : JP20H03296
Organisme : Japan Society for the Promotion of Science
ID : JP19K06768
Organisme : Japan Society for the Promotion of Science
ID : JP20K22741
Organisme : the Takeda Science Foundation
ID : none
Organisme : the Uehara Memorial Foundation
ID : none
Organisme : the ONO Medical Research Foundation
ID : none
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