Oral Sucrosomial Iron Is as Effective as Intravenous Ferric Carboxy-Maltose in Treating Anemia in Patients with Ulcerative Colitis.
Administration, Intravenous
Administration, Oral
Adult
Aged
Anemia, Iron-Deficiency
/ drug therapy
Colitis, Ulcerative
/ complications
Comparative Effectiveness Research
Female
Ferric Compounds
/ administration & dosage
Ferric Oxide, Saccharated
/ administration & dosage
Ferritins
/ blood
Hematinics
/ administration & dosage
Hemoglobins
/ drug effects
Humans
Iron
/ blood
Male
Maltose
/ administration & dosage
Middle Aged
Prospective Studies
Treatment Outcome
anemia
clinical
iron
ulcerative colitis
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
12 Feb 2021
12 Feb 2021
Historique:
received:
27
12
2020
revised:
01
02
2021
accepted:
09
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Anemia is a frequent complication of ulcerative colitis, and is frequently caused by iron deficiency. Oral iron supplementation displays high rates of gastrointestinal adverse effects. However, the formulation of sucrosomial iron (SI) has shown higher tolerability. We performed a prospective study to compare the effectiveness and tolerability of oral SI and intravenous ferric carboxy-maltose (FCM) in patients with ulcerative colitis in remission and mild-to-moderate anemia. Patients were randomized 1:1 to receive 60 mg/day for 8 weeks and then 30 mg/day for 4 weeks of oral SI or intravenous 1000 mg of FCM at baseline. Hemoglobin and serum levels of iron and ferritin were assessed after 4, 8, and 12 weeks from baseline. Hemoglobin and serum iron increased in both groups after 4 weeks of therapy, and remained stable during follow up, without significant treatment or treatment-by-time interactions (
Identifiants
pubmed: 33673371
pii: nu13020608
doi: 10.3390/nu13020608
pmc: PMC7917674
pii:
doi:
Substances chimiques
Ferric Compounds
0
Hematinics
0
Hemoglobins
0
ferric carboxymaltose
6897GXD6OE
Maltose
69-79-4
Ferritins
9007-73-2
Iron
E1UOL152H7
Ferric Oxide, Saccharated
FZ7NYF5N8L
Types de publication
Equivalence Trial
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
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