Tertiary Oxidation of Deoxycholate Is Predictive of CYP3A Activity in Dogs.

Adult Animals Cytochrome P-450 CYP3A / metabolism Cytochrome P-450 CYP3A Inhibitors / metabolism Deoxycholic Acid / metabolism Dogs Enzyme Activation / drug effects Female Forecasting GABA Modulators / metabolism Humans Ketoconazole / metabolism Male Microsomes, Liver / drug effects Midazolam / metabolism Oxidation-Reduction / drug effects

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
05 2021
Historique:
received: 20 01 2021
accepted: 26 02 2021
pubmed: 7 3 2021
medline: 10 2 2022
entrez: 6 3 2021
Statut: ppublish

Résumé

Deoxycholic acid (DCA, 3

Identifiants

DOI: 10.1124/dmd.121.000385 PMID: 33674269
pubmed: 33674269
pii: dmd.121.000385
doi: 10.1124/dmd.121.000385
doi:

Substances chimiques

Cytochrome P-450 CYP3A Inhibitors 0
GABA Modulators 0
Deoxycholic Acid 005990WHZZ
Cytochrome P-450 CYP3A EC 1.14.14.1
Midazolam R60L0SM5BC
Ketoconazole R9400W927I

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

369-378

Informations de copyright

Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Wushuang Zeng (W)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Lanlan Gui (L)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Xianwen Tan (X)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Pingping Zhu (P)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Yiting Hu (Y)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Qingliang Wu (Q)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Xuejing Li (X)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Lian Yang (L)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Wei Jia (W)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Changxiao Liu (C)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.).

Ke Lan (K)

Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China (W.Z., L.G., X.T., P.Z., Y.H., Q.W., K.L.); Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (X.L., L.Y., K.L.); WestChina-Frontier PharmaTech Co., Ltd., Chengdu, China (L.Y.); School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China (W.J.); and State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.L.) lanwoco@scu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Eucaryotes › Animaux › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-3 de cytochromes P450 › Cytochrome P-450 CYP3A › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs des enzymes du cytochrome P-450 › Inhibiteurs du cytochrome P-450 CYP3A › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholanes › Acides choliques › Acide désoxycholique › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Métabolisme › Activation enzymatique › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Sciences sociales › Prévision › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Modulateurs GABA › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Kétoconazole › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Midazolam › Tertiary Oxidation of Deoxycholate Is...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Tertiary Oxidation of Deoxycholate Is...