Deciphering the state of immune silence in fatal COVID-19 patients.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 03 2021
05 03 2021
Historique:
received:
03
10
2020
accepted:
31
01
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
17
3
2021
Statut:
epublish
Résumé
Since the beginning of the SARS-CoV-2 pandemic, COVID-19 appeared as a unique disease with unconventional tissue and systemic immune features. Here we show a COVID-19 immune signature associated with severity by integrating single-cell RNA-seq analysis from blood samples and broncho-alveolar lavage fluids with clinical, immunological and functional ex vivo data. This signature is characterized by lung accumulation of naïve lymphoid cells associated with a systemic expansion and activation of myeloid cells. Myeloid-driven immune suppression is a hallmark of COVID-19 evolution, highlighting arginase-1 expression with immune regulatory features of monocytes. Monocyte-dependent and neutrophil-dependent immune suppression loss is associated with fatal clinical outcome in severe patients. Additionally, our analysis shows a lung CXCR6
Identifiants
pubmed: 33674591
doi: 10.1038/s41467-021-21702-6
pii: 10.1038/s41467-021-21702-6
pmc: PMC7935849
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1428Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
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