In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP).


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
05 03 2021
Historique:
received: 07 08 2020
accepted: 11 02 2021
entrez: 6 3 2021
pubmed: 7 3 2021
medline: 15 12 2021
Statut: epublish

Résumé

Plasmodium falciparum malaria contributes to a significant global disease burden. Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime vaccine candidate. Inhibitory monoclonal antibodies (mAbs) against CSP map to either a short junctional sequence or the central (NPNA)

Identifiants

pubmed: 33674699
doi: 10.1038/s41598-021-84622-x
pii: 10.1038/s41598-021-84622-x
pmc: PMC7970865
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antibodies, Protozoan 0
Malaria Vaccines 0
Protozoan Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

5318

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Auteurs

Merricka C Livingstone (MC)

Structural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Alexis A Bitzer (AA)

Structural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Alish Giri (A)

Structural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Kun Luo (K)

Structural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Rajeshwer S Sankhala (RS)

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Misook Choe (M)

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Xiaoyan Zou (X)

Malaria Department, Naval Medical Research Center, Silver Spring, MD, USA.

S Moses Dennison (SM)

Center for Human Systems Immunology, Duke University Medical Center, Durham, NC, USA.
Departments of Surgery, Duke University Medical Center, Durham, NC, USA.

Yuanzhang Li (Y)

Statistics and Epidemiology Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

William Washington (W)

Statistics and Epidemiology Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Viseth Ngauy (V)

Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Georgia D Tomaras (GD)

Center for Human Systems Immunology, Duke University Medical Center, Durham, NC, USA.
Departments of Surgery, Duke University Medical Center, Durham, NC, USA.
Departments of Immunology, Duke University Medical Center, Durham, NC, USA.
Departments of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA.

M Gordon Joyce (MG)

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Adrian H Batchelor (AH)

Structural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Sheetij Dutta (S)

Structural Vaccinology Lab, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA. sheetij.dutta.civ@mail.mil.

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