Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature.
CD8 positive T-lymphocytes
Pneumonitis
SARS-CoV-2
Journal
Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
23
12
2020
accepted:
09
02
2021
pubmed:
7
3
2021
medline:
10
4
2021
entrez:
6
3
2021
Statut:
ppublish
Résumé
As of October 2020, there are over 40 million confirmed cases, and more than 1 million confirmed deaths of Covid-19 worldwide. The main cause of death in hospitalized patients is a respiratory failure due to acute respiratory distress syndrome. It has been suggested that the very intense immune response induces diffuse alveolar damage that far exceeds the harm that would have been caused by virus replication per se, resulting in lethal tissue destruction. We present a detailed report of the histopathological findings on cryo transbronchial biopsy in the patient with persistent (3 months) interstitial pneumonitis and severe CD8 positive cell infiltration in the lungs due to SARS-CoV-2 infection. CD8 positive T-lymphocytes have a great potential to damage tissue either through direct cytotoxicity or through cytokines release.
Identifiants
pubmed: 33676105
pii: S0344-0338(21)00041-8
doi: 10.1016/j.prp.2021.153380
pmc: PMC7883708
pii:
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
153380Informations de copyright
Copyright © 2021 Elsevier GmbH. All rights reserved.
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