Adrenal androgens, adrenarche, and zona reticularis: A human affair?
Adrenal androgens
Adrenarche
Differentiation
Organogenesis
PKA
Zona reticularis
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 05 2021
15 05 2021
Historique:
received:
31
12
2020
revised:
11
02
2021
accepted:
01
03
2021
pubmed:
8
3
2021
medline:
1
12
2021
entrez:
7
3
2021
Statut:
ppublish
Résumé
In humans, reticularis cells of the adrenal cortex fuel the production of androgen steroids, constituting the driver of numerous morphological changes during childhood. These steps are considered a precocious stage of sexual maturation and are grouped under the term "adrenarche". This review describes the molecular and enzymatic characteristics of the zona reticularis, along with the possible signals and mechanisms that control its emergence and the associated clinical features. We investigate the differences between species and discuss new studies such as genetic lineage tracing and transcriptomic analysis, highlighting the rodent inner cortex's cellular and molecular heterogeneity. The recent development and characterization of mouse models deficient for Prkar1a presenting with adrenocortical reticularis-like features prompt us to review our vision of the mouse adrenal gland maturation. We expect these new insights will help increase our understanding of the adrenarche process and the pathologies associated with its deregulation.
Identifiants
pubmed: 33676986
pii: S0303-7207(21)00083-6
doi: 10.1016/j.mce.2021.111239
pii:
doi:
Substances chimiques
Androgens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111239Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.