Effect of Growth Hormone on Neuropsychological Outcomes and Quality of Life of Patients with Traumatic Brain Injury: A Systematic Review.


Journal

Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626

Informations de publication

Date de publication:
01 06 2021
Historique:
pubmed: 9 3 2021
medline: 3 2 2022
entrez: 8 3 2021
Statut: ppublish

Résumé

One of the most devastating chronic consequences of traumatic brain injury (TBI) is cognitive impairment. One of the possible underlying causes is growth hormone deficiency (GHD) caused by TBI-induced hypopituitarism. Currently, TBI patients are not routinely screened for pituitary function, and there are no standard therapies when GHD is diagnosed. Further, the possible positive effects of GH replacement on cognitive function and quality of life after TBI are not well established. We aimed to assess the current knowledge regarding the effect of GH therapy on cognitive function and quality of life after TBI. We performed a literature search in PubMed, Embase, and Central

Identifiants

pubmed: 33677992
doi: 10.1089/neu.2020.7265
pmc: PMC8672110
doi:

Substances chimiques

Growth Hormone 9002-72-6

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1467-1483

Subventions

Organisme : NIA NIH HHS
ID : R01 AG068295
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL077256
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG072295
Pays : United States

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Auteurs

Nikolett Szarka (N)

Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.

Dora Szellar (D)

Department of Pediatrics, University of Pecs Medical School, Pecs, Hungary.

Szabolcs Kiss (S)

Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.

Nelli Farkas (N)

Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.

Zsolt Szakacs (Z)

Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.

Andras Czigler (A)

Department of Neurosurgery and Szentagothai Research Center, University of Pecs Medical School, Pecs, Hungary.

Zoltan Ungvari (Z)

International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Peter Hegyi (P)

Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.

Andras Buki (A)

Department of Neurosurgery and Szentagothai Research Center, University of Pecs Medical School, Pecs, Hungary.

Peter Toth (P)

Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Department of Neurosurgery and Szentagothai Research Center, University of Pecs Medical School, Pecs, Hungary.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary.

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