Antigen-Specific Treatment Modalities in MS: The Past, the Present, and the Future.
Adoptive Transfer
/ adverse effects
Animals
Autoimmunity
Desensitization, Immunologic
/ adverse effects
Diffusion of Innovation
Forecasting
History, 20th Century
History, 21st Century
Humans
Immune Tolerance
Multiple Sclerosis
/ history
Myelin Proteins
/ administration & dosage
Peptide Fragments
/ administration & dosage
Vaccination
/ adverse effects
Vaccines
/ adverse effects
antigen-specific therapy
experimental autoimmune encephalomyelitis
multiple sclerosis
myelin
tolerance induction
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
10
2020
accepted:
04
01
2021
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
15
9
2021
Statut:
epublish
Résumé
Antigen-specific therapy for multiple sclerosis may lead to a more effective therapy by induction of tolerance to a wide range of myelin-derived antigens without hampering the normal surveillance and effector function of the immune system. Numerous attempts to restore tolerance toward myelin-derived antigens have been made over the past decades, both in animal models of multiple sclerosis and in clinical trials for multiple sclerosis patients. In this review, we will give an overview of the current approaches for antigen-specific therapy that are in clinical development for multiple sclerosis as well provide an insight into the challenges for future antigen-specific treatment strategies for multiple sclerosis.
Identifiants
pubmed: 33679769
doi: 10.3389/fimmu.2021.624685
pmc: PMC7933447
doi:
Substances chimiques
Myelin Proteins
0
Peptide Fragments
0
Vaccines
0
Types de publication
Historical Article
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
624685Informations de copyright
Copyright © 2021 Derdelinckx, Cras, Berneman and Cools.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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