Exploring the Role of ATP-Citrate Lyase in the Immune System.
ATP-citrate lyase
acetyl-CoA
histone acetylation
macrophage
metabolism
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
11
2020
accepted:
04
01
2021
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Studies over the past decade have revealed that metabolism profoundly influences immune responses. In particular, metabolism causes epigenetic regulation of gene expression, as a growing number of metabolic intermediates are substrates for histone post-translational modifications altering chromatin structure. One of these substrates is acetyl-coenzyme A (CoA), which donates an acetyl group for histone acetylation. Cytosolic acetyl-CoA is also a critical substrate for
Identifiants
pubmed: 33679780
doi: 10.3389/fimmu.2021.632526
pmc: PMC7930476
doi:
Substances chimiques
Fatty Acids
0
Histones
0
Acetyl Coenzyme A
72-89-9
ATP Citrate (pro-S)-Lyase
EC 2.3.3.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
632526Informations de copyright
Copyright © 2021 Dominguez, Brüne and Namgaladze.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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