Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
08 03 2021
Historique:
received: 02 11 2020
accepted: 12 02 2021
entrez: 9 3 2021
pubmed: 10 3 2021
medline: 23 3 2021
Statut: epublish

Résumé

Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories over 122 years. We generate a core gene phylogeny and determine the presence of antimicrobial resistance genes and variation within the tox gene of 291 tox

Identifiants

pubmed: 33686077
doi: 10.1038/s41467-021-21870-5
pii: 10.1038/s41467-021-21870-5
pmc: PMC7940655
doi:

Substances chimiques

Anti-Infective Agents 0
Diphtheria Toxin 0
Diphtheria Toxoid 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1500

Subventions

Organisme : World Health Organization
ID : 001
Pays : International
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR200640
Pays : United Kingdom

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Auteurs

Robert C Will (RC)

Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.

Thandavarayan Ramamurthy (T)

Translational Health Science and Technology Institute, Faridabad, India.

Naresh Chand Sharma (NC)

Maharishi Valmiki Infectious Diseases Hospital, Delhi, India.

Balaji Veeraraghavan (B)

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Lucky Sangal (L)

World Health Organization, New Delhi, India.

Pradeep Haldar (P)

Ministry of Health and Family Welfare, Govt. of India, New Delhi, India.

Agila Kumari Pragasam (AK)

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Karthick Vasudevan (K)

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Dhirendra Kumar (D)

Translational Health Science and Technology Institute, Faridabad, India.
Maharishi Valmiki Infectious Diseases Hospital, Delhi, India.

Bhabatosh Das (B)

Translational Health Science and Technology Institute, Faridabad, India.

Eva Heinz (E)

Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.

Vyacheslav Melnikov (V)

Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.

Stephen Baker (S)

Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.

Vartul Sangal (V)

Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Gordon Dougan (G)

Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.

Ankur Mutreja (A)

Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, UK. am872@medschl.cam.ac.uk.
Translational Health Science and Technology Institute, Faridabad, India. am872@medschl.cam.ac.uk.

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Classifications MeSH