Biotransformation of Phlorizin by Eurotium cristatum to Increase the Antioxidant and Antibacterial Activity of Docynia indica Leaves.
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
02
02
2020
accepted:
05
02
2021
pubmed:
10
3
2021
medline:
15
5
2021
entrez:
9
3
2021
Statut:
ppublish
Résumé
Docynia indica is used as a plant resource for both medicine and food in minority areas of southwestern China and Southeast of Asia, especially Docynia indica leaves, which are often used as a kind of functional tea in daily life. In our previous research, it has found that D. indica is rich in polyphenols (mainly phlorizin (PHZ)). Although PHZ is the first polyphenolic competitive inhibitor of sodium-dependent glucose transporters (SGLTs) to be discovered, the promotion and application of PHZ are limited due to its extremely low bioavailability. As a kind of aglycons, phloretin (PHT) possesses a better bioavailability and bioactivity than PHZ. Therefore, the conversion of PHZ to PHT in D. indica leaves by the method of biotransformation can be applied to solve the above issue. In this study, Aspergillus niger and Eurotium cristatum were used to transform PHZ to PHT in D. indica. Compared with Aspergillus niger, Eurotium cristatum can cause the equimolar conversion of PHZ to PHT. However, Aspergillus niger resulted in the complete degradation of PHZ. In the process of deep fermentation, PHZ in D. indica leaves was gradually biotransformed into PHT, and its content was as high as ~ 12% after fermentation. With the increase of PHT content, the antioxidant and antibacterial activity of Docynia indica leaves increased. By the acute toxicity evaluation, it was confirmed that Docynia indica leaves and Eurotium cristatum fermented leaves were much safer. These results indicate that Eurotium cristatum fermentation has the ability to transform the functional compounds in Docynia indica leaves and increase the antioxidant and antibacterial activity of Docynia indica, thus making it a substitute for PHT and functional tea.
Identifiants
pubmed: 33686505
doi: 10.1007/s00284-021-02366-3
pii: 10.1007/s00284-021-02366-3
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antioxidants
0
Phlorhizin
CU9S17279X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1590-1601Subventions
Organisme : Education Department of Sichuan Province
ID : 18CZ0005
Organisme : Education Department of Sichuan Province
ID : CC17Z03
Organisme : Department of Science and Technology of Sichuan Province
ID : 2020YJ0372
Organisme : Department of Science and Technology of Sichuan Province
ID : 2019YFS0107
Organisme : Department of Science and Technology of Sichuan Province
ID : 2018JY0362
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