The Mediating Effect of Insomnia on the Relationship between Panic Symptoms and Depression in Patients with Panic Disorder.
Comorbidity
Depression
Insomnia
Mediator
Panic Disorder
Journal
Journal of Korean medical science
ISSN: 1598-6357
Titre abrégé: J Korean Med Sci
Pays: Korea (South)
ID NLM: 8703518
Informations de publication
Date de publication:
08 Mar 2021
08 Mar 2021
Historique:
received:
07
07
2020
accepted:
22
11
2020
entrez:
9
3
2021
pubmed:
10
3
2021
medline:
14
10
2021
Statut:
epublish
Résumé
This study aimed to determine if sleep disturbances may mediate the relationship between panic symptoms and depression in patients with panic disorder (PD). Electronic medical records were retrospectively reviewed for 110 consecutive patients with diagnosed PD in an outpatient clinic between October 2018 and December 2019. Measurements include the PD Severity Scale, Beck Depression Inventory-II (BDI-II) and Insomnia Severity Index (ISI). Statistical analyses were performed to assess any potential relationship between PD, insomnia and depression. Of the PD patients, 88 (80%) and 89 (80.9%) had comorbid depression (BDI-II ≥ 14) and insomnia (Korean version of the ISI ≥ 8), respectively. In a mediation model using insomnia as the mediating variable, the total effect of panic symptom severity on depression was significant ( Both depressive symptoms and insomnia are common in patients with PD and depression was partially mediated by insomnia in these patients. These results suggest that an intervention for insomnia in patients with PD might help prevent the development of depression.
Sections du résumé
BACKGROUND
BACKGROUND
This study aimed to determine if sleep disturbances may mediate the relationship between panic symptoms and depression in patients with panic disorder (PD).
METHODS
METHODS
Electronic medical records were retrospectively reviewed for 110 consecutive patients with diagnosed PD in an outpatient clinic between October 2018 and December 2019. Measurements include the PD Severity Scale, Beck Depression Inventory-II (BDI-II) and Insomnia Severity Index (ISI). Statistical analyses were performed to assess any potential relationship between PD, insomnia and depression.
RESULTS
RESULTS
Of the PD patients, 88 (80%) and 89 (80.9%) had comorbid depression (BDI-II ≥ 14) and insomnia (Korean version of the ISI ≥ 8), respectively. In a mediation model using insomnia as the mediating variable, the total effect of panic symptom severity on depression was significant (
CONCLUSION
CONCLUSIONS
Both depressive symptoms and insomnia are common in patients with PD and depression was partially mediated by insomnia in these patients. These results suggest that an intervention for insomnia in patients with PD might help prevent the development of depression.
Identifiants
pubmed: 33686808
pii: 36.e30
doi: 10.3346/jkms.2021.36.e30
pmc: PMC7940123
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e30Informations de copyright
© 2021 The Korean Academy of Medical Sciences.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
Références
J Clin Psychiatry. 2011 Dec;72(12):1628-35
pubmed: 21457675
J Clin Neurol. 2014 Jul;10(3):210-5
pubmed: 25045373
Psychol Med. 2002 May;32(4):719-28
pubmed: 12102386
J Affect Disord. 1986 Sep-Oct;11(2):105-14
pubmed: 2948982
Int J Endocrinol. 2010;2010:759234
pubmed: 20628523
Curr Psychiatry Rep. 2013 Dec;15(12):418
pubmed: 24189774
J Nerv Ment Dis. 1978 Dec;166(12):846-50
pubmed: 31415
Sleep Med. 2001 Jul;2(4):297-307
pubmed: 11438246
Arch Gen Psychiatry. 1982 Jun;39(6):687-9
pubmed: 7092502
Arch Gen Psychiatry. 2006 Apr;63(4):415-24
pubmed: 16585471
Arch Gen Psychiatry. 1990 Sep;47(9):805-8
pubmed: 2393338
Arch Gen Psychiatry. 1988 May;45(5):437-43
pubmed: 3282480
Multivariate Behav Res. 2007 Jan-Mar;42(1):185-227
pubmed: 26821081
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Arch Womens Ment Health. 2014 Jun;17(3):189-98
pubmed: 24647705
J Anxiety Disord. 2008;22(3):453-63
pubmed: 17449220
Behav Ther. 2009 Sep;40(3):239-50
pubmed: 19647525
Monogr Gesamtgeb Psychiatr Psychiatry Ser. 1988;50:1-421
pubmed: 3352616
Can Psychiatr Assoc J. 1979 Jun;24(4):317-22
pubmed: 466626
Depress Anxiety. 2009;26(8):E120-3
pubmed: 19373866
J Affect Disord. 1984 Feb;6(1):67-82
pubmed: 6231331
Arch Gen Psychiatry. 1998 Sep;55(9):801-8
pubmed: 9736006
Psychopathology. 2001 Nov-Dec;34(6):278-88
pubmed: 11847487
Depress Anxiety. 2002;15(4):183-5
pubmed: 12112724
J Clin Psychiatry. 1990 Nov;51 Suppl:35-9
pubmed: 2228992
JAMA. 1991 Feb 13;265(6):742-6
pubmed: 1990190
Compr Psychiatry. 1981 Nov-Dec;22(6):612-8
pubmed: 7307477
BMC Psychiatry. 2016 Nov 5;16(1):375
pubmed: 27816065
Am J Psychiatry. 2004 Dec;161(12):2207-14
pubmed: 15569891
Arch Gen Psychiatry. 1984 Dec;41(12):1129-35
pubmed: 6508503
J Am Acad Child Adolesc Psychiatry. 1999 Dec;38(12):1490-6
pubmed: 10596248
Behav Res Methods Instrum Comput. 2004 Nov;36(4):717-31
pubmed: 15641418
J Pers Soc Psychol. 1986 Dec;51(6):1173-82
pubmed: 3806354
J Psychiatr Res. 1998 Nov-Dec;32(6):335-45
pubmed: 9844949
J Abnorm Psychol. 1991 Aug;100(3):316-36
pubmed: 1918611
Psychiatry Investig. 2017 Jan;14(1):30-36
pubmed: 28096872
Am J Psychiatry. 2004 Sep;161(9):1581-7
pubmed: 15337647
Sleep. 2008 Nov;31(11):1579-85
pubmed: 19014078
J Clin Psychiatry. 1991 Jun;52 Suppl:48-54
pubmed: 2050649
Br J Psychiatry Suppl. 1996 Jun;(30):58-67
pubmed: 8864150
Compr Psychiatry. 1998 May-Jun;39(3):149-51
pubmed: 9606581
Am J Psychiatry. 1997 Nov;154(11):1571-5
pubmed: 9356566
Am J Psychiatry. 1990 Sep;147(9):1189-94
pubmed: 2104515
J Affect Disord. 2011 Dec;135(1-3):10-9
pubmed: 21300408
Compr Psychiatry. 1995 Jan-Feb;36(1):25-30
pubmed: 7705084
Depress Anxiety. 2015 Jul;32(7):509-17
pubmed: 26014910
Curr Biol. 2007 Oct 23;17(20):R877-8
pubmed: 17956744
J Psychiatr Res. 2001 Sep-Oct;35(5):293-6
pubmed: 11591432