Cancer immunotherapy: Macs in the middle.

CD8-Positive T-Lymphocytes Humans Immunotherapy Neoplasms / therapy

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
09 03 2021
Historique:
entrez: 10 3 2021
pubmed: 11 3 2021
medline: 1 9 2021
Statut: ppublish

Résumé

Response to immune checkpoint blockade cancer immunotherapy is variable, but the mechanisms that underlie this variability remain unclear. In a recent issue of Nature Medicine, Yu et al. demonstrate that liver metastases limit immunotherapy efficacy by promoting macrophage-mediated elimination of tumor-specific CD8

Identifiants

DOI: 10.1016/j.immuni.2021.02.012 PMID: 33691132
pubmed: 33691132
pii: S1074-7613(21)00078-9
doi: 10.1016/j.immuni.2021.02.012
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

409-411

Commentaires et corrections

Type : CommentOn

Informations de copyright

Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests S.T. receives research funding from Bristol-Myers Squibb and Iovance Biotherapeutics.

Auteurs

Naglaa H Shoukry (NH)

Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada; Institut du cancer de Montréal, Montréal, Québec, Canada; Département de médecine, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada. Electronic address: naglaa.shoukry@umontreal.ca.

Simon Turcotte (S)

Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada; Institut du cancer de Montréal, Montréal, Québec, Canada; Service de chirurgie hépatobiliaire et pancréatique et de transplantation hépatique du Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Cancer immunotherapy: Macs in the middle.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cancer immunotherapy: Macs in the middle.
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Cancer immunotherapy: Macs in the middle.
questionsmedicales.fr › Tumeurs › Cancer immunotherapy: Macs in the middle.