Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against Alzheimer's disease.

Acetylcholinesterase / chemistry Alzheimer Disease / drug therapy Animals Butyrylcholinesterase / chemistry Cell Survival / drug effects Cholinesterase Inhibitors / chemical synthesis Chromones / chemical synthesis Dose-Response Relationship, Drug Drug Design Hydrogen Peroxide Ligands Models, Molecular Molecular Docking Simulation Molecular Structure PC12 Cells Pharmacokinetics Protein Conformation Pyridinium Compounds / chemistry Rats
Alzheimer’s disease Anti-amyloid aggregation Cholinesterase inhibitors Chromone Neuroprotective activity Pyridinium salts

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
05 2021
Historique:
received: 24 08 2020
revised: 16 01 2021
accepted: 13 02 2021
pubmed: 11 3 2021
medline: 16 10 2021
entrez: 10 3 2021
Statut: ppublish

Résumé

A new serise of 7-hydroxy-chromone derivatives bearing pyridine moiety were synthesized, and evaluated as multifunctional agents against Alzheimer's disease (AD). Most of the compounds were good AChE inhibitors (IC

Identifiants

DOI: 10.1016/j.bioorg.2021.104750 PMID: 33691251
pubmed: 33691251
pii: S0045-2068(21)00127-9
doi: 10.1016/j.bioorg.2021.104750
pii:
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Chromones 0
Ligands 0
Pyridinium Compounds 0
Hydrogen Peroxide BBX060AN9V
Acetylcholinesterase EC 3.1.1.7
Butyrylcholinesterase EC 3.1.1.8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104750

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Shahin Abdpour (S)

Department of Chemistry, University of Zanjan, Zanjan, Iran.

Leili Jalili-Baleh (L)

The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 1417614411, Iran.

Hamid Nadri (H)

Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Hamid Forootanfar (H)

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

Syed Nasir Abbas Bukhari (SNA)

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka 2014, Saudi Arabia.

Ali Ramazani (A)

Department of Chemistry, University of Zanjan, Zanjan, Iran.

Seyed Esmaeil Sadat Ebrahimi (SES)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176, Iran.

Alireza Foroumadi (A)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176, Iran.

Mehdi Khoobi (M)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176, Iran; Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 1417614411, Iran. Electronic address: m-khoobi@tums.ac.ir.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Eucaryotes › Animaux › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Cellules › Cellules chromaffines › Cellules PC12 › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Composés de pyridinium › Chromone derivatives bearing pyridinium moiety...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Chromone derivatives bearing pyridinium moiety...