The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
10 03 2021
10 03 2021
Historique:
received:
03
07
2020
accepted:
11
02
2021
entrez:
11
3
2021
pubmed:
12
3
2021
medline:
10
8
2021
Statut:
epublish
Résumé
In the adult vertebrate brain, enzymatic removal of the extracellular matrix (ECM) is increasingly recognized to promote learning, memory recall, and restorative plasticity. The impact of the ECM on translaminar dynamics during cortical circuit processing is still not understood. Here, we removed the ECM in the primary auditory cortex (ACx) of adult Mongolian gerbils using local injections of hyaluronidase (HYase). Using laminar current-source density (CSD) analysis, we found layer-specific changes of the spatiotemporal synaptic patterns with increased cross-columnar integration and simultaneous weakening of early local sensory input processing within infragranular layers Vb. These changes had an oscillatory fingerprint within beta-band (25-36 Hz) selectively within infragranular layers Vb. To understand the laminar interaction dynamics after ECM digestion, we used time-domain conditional Granger causality (GC) measures to identify the increased drive of supragranular layers towards deeper infragranular layers. These results showed that ECM degradation altered translaminar cortical network dynamics with a stronger supragranular lead of the columnar response profile.
Identifiants
pubmed: 33692502
doi: 10.1038/s42003-021-01837-4
pii: 10.1038/s42003-021-01837-4
pmc: PMC7946889
doi:
Substances chimiques
Hyaluronoglucosaminidase
EC 3.2.1.35
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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