Peak glucose during an oral glucose tolerance test is associated with future diabetes risk in adults with cystic fibrosis.
Adult
Blood glucose variables
Cystic fibrosis
Lung function
Oral glucose tolerance test
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
05
11
2020
accepted:
11
01
2021
pubmed:
12
3
2021
medline:
23
2
2022
entrez:
11
3
2021
Statut:
ppublish
Résumé
Cystic fibrosis-related diabetes (CFRD) affects up to 50% of adults with cystic fibrosis (CF) and its presence is associated with adverse effects on nutritional status and pulmonary function. Early diagnosis could minimise CFRD morbidity, yet current methods of an OGTT at 0 and 2 h yield unreliable results. Our aim was to determine which indices from a 2 h OGTT with sampling every 30 min might improve prediction of CFRD. Cross-sectional analysis at baseline (n = 293) and observational prospective analysis (n = 185; mean follow-up of 7.5 ± 4.2 years) of the Montreal Cystic Fibrosis Cohort were performed. Blood glucose and insulinaemia OGTT variables were studied in relation to lung function (forced expiratory volume in 1 s [FEV1]), BMI and risk of developing CFRD. At baseline, maximum OGTT glucose (G In adults with CF, G
Identifiants
pubmed: 33693987
doi: 10.1007/s00125-021-05423-5
pii: 10.1007/s00125-021-05423-5
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1332-1341Subventions
Organisme : CIHR
Pays : Canada
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