MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease.

Animals Epithelial-Mesenchymal Transition Heterogeneous-Nuclear Ribonucleoproteins / metabolism Human Umbilical Vein Endothelial Cells / metabolism Humans Hypertension, Pulmonary / genetics Mice Polypyrimidine Tract-Binding Protein / metabolism RNA, Long Noncoding / genetics Transcriptome Vascular Remodeling
endothelial cells lncRNA microRNAs pulmonary arterial hypertension vascular remodeling

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
16 04 2021
Historique:
pubmed: 12 3 2021
medline: 8 1 2022
entrez: 11 3 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/CIRCRESAHA.120.318124 PMID: 33703914 PMC: PMC7610629
pubmed: 33703914
doi: 10.1161/CIRCRESAHA.120.318124
pmc: PMC7610629
mid: EMS119148
doi:

Substances chimiques

Heterogeneous-Nuclear Ribonucleoproteins 0
PTBP1 protein, human 0
RNA, Long Noncoding 0
long non-coding RNA MIR503HG, human 0
Polypyrimidine Tract-Binding Protein 139076-35-0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1173-1190

Subventions

Organisme : British Heart Foundation
ID : SP/17/3/33020
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/40/33650
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/14/3/30706
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 208402
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL135093
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130423
Pays : United States
Organisme : British Heart Foundation
ID : PG/21/10624
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL148167
Pays : United States
Organisme : British Heart Foundation
ID : CH/09/001/25945
Pays : United Kingdom
Organisme : European Research Council
ID : 338991
Pays : International
Organisme : British Heart Foundation
ID : CH/11/2/28733
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/20/10347
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/38/32351
Pays : United Kingdom

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Auteurs

João P Monteiro (JP)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Julie Rodor (J)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Axelle Caudrillier (A)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Jessica P Scanlon (JP)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Ana-Mishel Spiroski (AM)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Tatiana Dudnakova (T)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Beatrice Pflüger-Müller (B)

Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).
German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).

Alena Shmakova (A)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Alex von Kriegsheim (A)

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine (A.v.K.), University of Edinburgh, Edinburgh, Scotland.

Lin Deng (L)

Richard S Taylor (RS)

The Roslin Institute and Royal (Dick) School of Veterinary Studies (R.S.T.), University of Edinburgh, Edinburgh, Scotland.

John R Wilson-Kanamori (JR)

The Queen's Medical Research Institute, Centre for Inflammation Research (J.R.W.-K., N.C.H.), University of Edinburgh, Edinburgh, Scotland.

Shiau-Haln Chen (SH)

Kevin Stewart (K)

Adrian Thomson (A)

Tijana Mitić (T)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

John D McClure (JD)

Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Centre, University of Glasgow, Glasgow, United Kingdom (J.D.M., A.C.B.).

Jean Iynikkel (J)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Patrick W F Hadoke (PWF)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Laura Denby (L)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Angela C Bradshaw (AC)

Institute of Cardiovascular and Medical Sciences, British Heart Foundation (BHF) Glasgow Centre, University of Glasgow, Glasgow, United Kingdom (J.D.M., A.C.B.).

Paola Caruso (P)

BHF Cambridge (CRE), University of Cambridge, Cambridge, United Kingdom (P.C., N.W.M.).

Nicholas W Morrell (NW)

BHF Cambridge (CRE), University of Cambridge, Cambridge, United Kingdom (P.C., N.W.M.).

Jason C Kovacic (JC)

The Zena and Michael A. Wiener Cardiovascular Institute, School of Medicine at Mount Sinai, New York, New York (J.C.K.).
Victor Chang Cardiac Research Institute, Darlinghurst, Australia. (J.C.K.).

Igor Ulitsky (I)

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel (I.U.).

Neil C Henderson (NC)

The Queen's Medical Research Institute, Centre for Inflammation Research (J.R.W.-K., N.C.H.), University of Edinburgh, Edinburgh, Scotland.

Andrea Caporali (A)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

Matthias S Leisegang (MS)

Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).
German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).

Ralf P Brandes (RP)

Institute for Cardiovascular Physiology, Goethe University, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).
German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany (B.P.-M., M.S.L., R.P.B.).

Andrew H Baker (AH)

The Queen's Medical Research Institute, Centre for Cardiovascular Science (J.P.M., J.R., A. Caudrillier, J.P.S., A.-M.S., T.D., A.S., L. Deng, S.-H.C., K.S., A.T., T.M., J.I., P.W.F.H., L. Denby, A. Caporali, A.H.B.), University of Edinburgh, Edinburgh, Scotland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › MIR503HG Loss Promotes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › MIR503HG Loss Promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Ribonucléoprotéines nucléaires hétérogènes › MIR503HG Loss Promotes...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Cellules endothéliales de la veine ombilicale humaine › MIR503HG Loss Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › MIR503HG Loss Promotes...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hypertension pulmonaire › MIR503HG Loss Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › MIR503HG Loss Promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Facteurs d'épissage des ARN › Protéine PTB › MIR503HG Loss Promotes...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › MIR503HG Loss Promotes...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › MIR503HG Loss Promotes...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Remodelage vasculaire › MIR503HG Loss Promotes...