The pattern of runs of homozygosity and genomic inbreeding in world-wide sheep populations.
Autozygosity
Genomic inbreeding
ROH hotspot
Runs of homozygosity
Sheep
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
05
04
2020
revised:
21
02
2021
accepted:
04
03
2021
pubmed:
12
3
2021
medline:
1
4
2022
entrez:
11
3
2021
Statut:
ppublish
Résumé
Genome-wide pattern of runs of homozygosity (ROH) across ovine genome can provide a useful resource for studying diversity and demography history in sheep. We analyzed 50 k SNPs chip data of 2536 animals to identify pattern, distribution and level of ROHs in 68 global sheep populations. A total of 60,301 ROHs were detected in all breeds. The majority of the detected ROHs were <16 Mb and the average total number of ROHs per individual was 23.8 ± 13.8. The ROHs greater than 1 Mb covered on average 8.2% of the sheep autosomes, 1% of which was related to the ROHs with 1-4 Mb of length. The mean sum of ROH length in two-thirds of the populations was less than 250 Mb ranging from 21.7 to near 570 Mb. The level of genomic inbreeding was relatively low. The average of the inbreeding coefficients based on ROH (F
Identifiants
pubmed: 33705888
pii: S0888-7543(21)00086-0
doi: 10.1016/j.ygeno.2021.03.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1407-1415Informations de copyright
Copyright © 2021. Published by Elsevier Inc.