Gender-affirming hormone treatment causes changes in gender phenotype in a 12-lead electrocardiogram.
Early repolarization pattern
Electrocardiogram
Gender dysphoria
Gender-affirming hormone treatment
Sokolow-Lyon voltage
Journal
Heart rhythm
ISSN: 1556-3871
Titre abrégé: Heart Rhythm
Pays: United States
ID NLM: 101200317
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
26
01
2021
revised:
24
02
2021
accepted:
02
03
2021
pubmed:
12
3
2021
medline:
11
2
2022
entrez:
11
3
2021
Statut:
ppublish
Résumé
Men and women have specific patterns in an electrocardiogram (ECG) differentiated by J-point elevation and ST-segment angle. Although gender-affirming hormone treatment is one of the treatments for gender dysphoria, its influence on an ECG has not been clarified yet. The purpose of this study was to investigate ECG changes induced by gender-affirming hormone treatment. The study population consisted of 29 transgender males and 8 transgender females and 37 age- and sex-matched cisgender females and males. Male pattern was defined as J-point elevation > 0.1 mV and ST-segment angle > 20° in precordial leads. In the comparison between 29 transgender males and cisgender females, the prevalence of the male pattern (89.7% vs 6.9%; P < .001), prevalence of the early repolarization pattern (51.7% vs 17.2%; P = .01), J-point elevation (leads V Gender-affirming hormone treatment for gender dysphoria is accompanied by a change in ECG phenotype toward affirming gender, in which change in androgen level may be involved.
Sections du résumé
BACKGROUND
Men and women have specific patterns in an electrocardiogram (ECG) differentiated by J-point elevation and ST-segment angle. Although gender-affirming hormone treatment is one of the treatments for gender dysphoria, its influence on an ECG has not been clarified yet.
OBJECTIVE
The purpose of this study was to investigate ECG changes induced by gender-affirming hormone treatment.
METHODS
The study population consisted of 29 transgender males and 8 transgender females and 37 age- and sex-matched cisgender females and males. Male pattern was defined as J-point elevation > 0.1 mV and ST-segment angle > 20° in precordial leads.
RESULTS
In the comparison between 29 transgender males and cisgender females, the prevalence of the male pattern (89.7% vs 6.9%; P < .001), prevalence of the early repolarization pattern (51.7% vs 17.2%; P = .01), J-point elevation (leads V
CONCLUSION
Gender-affirming hormone treatment for gender dysphoria is accompanied by a change in ECG phenotype toward affirming gender, in which change in androgen level may be involved.
Identifiants
pubmed: 33706005
pii: S1547-5271(21)00201-0
doi: 10.1016/j.hrthm.2021.03.009
pii:
doi:
Substances chimiques
Androgens
0
Biomarkers
0
Hormones
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1203-1209Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.