Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control.

Animals Biological Clocks / physiology Cell Differentiation Homeodomain Proteins / genetics Humans Mice Mice, Knockout Mouse Embryonic Stem Cells / cytology Myocytes, Cardiac / cytology Organogenesis / physiology Sinoatrial Node / cytology Transcription Factors / genetics Zebrafish / embryology Zebrafish Proteins / genetics
Atrial fibrillation, sinus node dysfunction, cardiac rhythm control Gene regulatory networks SHOX2, transcription factor

Journal

Biochimica et biophysica acta. Gene regulatory mechanisms
ISSN: 1876-4320
Titre abrégé: Biochim Biophys Acta Gene Regul Mech
Pays: Netherlands
ID NLM: 101731723

Informations de publication

Date de publication:
Historique:
received: 02 11 2020
revised: 22 02 2021
accepted: 23 02 2021
pubmed: 12 3 2021
medline: 1 7 2021
entrez: 11 3 2021
Statut: ppublish

Résumé

The homeodomain transcription factor SHOX2 is involved in the development and function of the heart's primary pacemaker, the sinoatrial node (SAN), and has been associated with cardiac conduction-related diseases such as atrial fibrillation and sinus node dysfunction. To shed light on Shox2-dependent genetic processes involved in these diseases, we established a murine embryonic stem cell (ESC) cardiac differentiation model to investigate Shox2 pathways in SAN-like cardiomyocytes. Differential RNA-seq-based expression profiling of Shox2

Identifiants

DOI: 10.1016/j.bbagrm.2021.194702 PMID: 33706013
pubmed: 33706013
pii: S1874-9399(21)00020-1
doi: 10.1016/j.bbagrm.2021.194702
pii:
doi:

Substances chimiques

Homeodomain Proteins 0
Shox2 protein, mouse 0
Shox2 protein, zebrafish 0
Transcription Factors 0
Zebrafish Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

194702

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

S Hoffmann (S)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany; DZHK, German Centre for Cardiovascular Research, Partner Site Heidelberg/Mannheim, Germany.

S Schmitteckert (S)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany.

K Raedecke (K)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany; DZHK, German Centre for Cardiovascular Research, Partner Site Heidelberg/Mannheim, Germany.

D Rheinert (D)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany.

S Diebold (S)

Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Germany.

R Roeth (R)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany; nCounter Core Facility, Institute of Human Genetics, University of Heidelberg, Germany.

B Weiss (B)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany.

M Granzow (M)

Department of Human Genetics, Institute of Human Genetics, University of Heidelberg, Germany.

B Niesler (B)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany; DZHK, German Centre for Cardiovascular Research, Partner Site Heidelberg/Mannheim, Germany; nCounter Core Facility, Institute of Human Genetics, University of Heidelberg, Germany.

A Griesbeck (A)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany.

V Eckstein (V)

FACS Core Facility, Department of Medicine V, University Hospital Heidelberg, Germany.

W-H Zimmermann (WH)

Institute of Pharmacology and Toxicology, University Medical Center Goettingen, Germany; DZHK, German Centre for Cardiovascular Research, Partner Site Goettingen, Germany; Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), University of Goettingen, Germany.

S Just (S)

Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Germany.

G A Rappold (GA)

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Germany; DZHK, German Centre for Cardiovascular Research, Partner Site Heidelberg/Mannheim, Germany. Electronic address: Gudrun.Rappold@med.uni-heidelberg.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Network-driven discovery yields new insight...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Horloges biologiques › Network-driven discovery yields new insight...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Network-driven discovery yields new insight...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Network-driven discovery yields new insight...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Network-driven discovery yields new insight...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Network-driven discovery yields new insight...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Network-driven discovery yields new insight...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Cellules souches embryonnaires de souris › Network-driven discovery yields new insight...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Network-driven discovery yields new insight...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Organogenèse › Network-driven discovery yields new insight...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Système de conduction du coeur › Noeud sinuatrial › Network-driven discovery yields new insight...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Network-driven discovery yields new insight...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Network-driven discovery yields new insight...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › Network-driven discovery yields new insight...