Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
26
06
2020
revised:
06
01
2021
accepted:
05
03
2021
pubmed:
13
3
2021
medline:
26
2
2022
entrez:
12
3
2021
Statut:
ppublish
Résumé
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of SCLC uniquely upregulates MHC I, enriching for durable ICB benefit.
Identifiants
pubmed: 33707236
pii: 2159-8290.CD-20-0913
doi: 10.1158/2159-8290.CD-20-0913
pmc: PMC8338750
mid: NIHMS1684358
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1952-1969Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007627
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA251062
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA222657
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA214381
Pays : United States
Organisme : NIH HHS
ID : S10 OD018522
Pays : United States
Organisme : NIH HHS
ID : S10 OD026880
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL105373
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009172
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006516
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190394
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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