APTES monolayer coverage on self-assembled magnetic nanospheres for controlled release of anticancer drug Nintedanib.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 03 2021
Historique:
received: 10 10 2020
accepted: 16 02 2021
entrez: 12 3 2021
pubmed: 13 3 2021
medline: 15 12 2021
Statut: epublish

Résumé

The use of an appropriate delivery system capable of protecting, translocating, and selectively releasing therapeutic moieties to desired sites can promote the efficacy of an active compound. In this work, we have developed a nanoformulation which preserves its magnetization to load a model anticancerous drug and to explore the controlled release of the drug in a cancerous environment. For the preparation of the nanoformulation, self-assembled magnetic nanospheres (MNS) made of superparamagnetic iron oxide nanoparticles were grafted with a monolayer of (3-aminopropyl)triethoxysilane (APTES). A direct functionalization strategy was used to avoid the loss of the MNS magnetization. The successful preparation of the nanoformulation was validated by structural, microstructural, and magnetic investigations. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) were used to establish the presence of APTES on the MNS surface. The amine content quantified by a ninhydrin assay revealed the monolayer coverage of APTES over MNS. The monolayer coverage of APTES reduced only negligibly the saturation magnetization from 77 emu/g (for MNS) to 74 emu/g (for MNS-APTES). Detailed investigations of the thermoremanent magnetization were carried out to assess the superparamagnetism in the MNS. To make the nanoformulation pH-responsive, the anticancerous drug Nintedanib (NTD) was conjugated with MNS-APTES through the acid liable imine bond. At pH 5.5, which mimics a cancerous environment, a controlled release of 85% in 48 h was observed. On the other hand, prolonged release of NTD was found at physiological conditions (i.e., pH 7.4). In vitro cytotoxicity study showed dose-dependent activity of MNS-APTES-NTD for human lung cancer cells L-132. About 75% reduction in cellular viability for a 100 μg/mL concentration of nanoformulation was observed. The nanoformulation designed using MNS and monolayer coverage of APTES has potential in cancer therapy as well as in other nanobiological applications.

Identifiants

pubmed: 33707549
doi: 10.1038/s41598-021-84770-0
pii: 10.1038/s41598-021-84770-0
pmc: PMC7952395
doi:

Substances chimiques

Antineoplastic Agents 0
Delayed-Action Preparations 0
Indoles 0
Magnetite Nanoparticles 0
Propylamines 0
Protons 0
Silanes 0
nintedanib G6HRD2P839
amino-propyl-triethoxysilane L8S6UBW552

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5674

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Auteurs

V C Karade (VC)

School of Nanoscience and Technology, Shivaji University, Kolhapur, Maharashtra, 416004, India.
Optoelectronic Convergence Research Center and Department of Materials Science and Engineering, Chonnam National University, Gwangju, 500-757, South Korea.

A Sharma (A)

Semiconductor Physics, Chemnitz University of Technology, 09107, Chemnitz, Germany.

R P Dhavale (RP)

School of Nanoscience and Technology, Shivaji University, Kolhapur, Maharashtra, 416004, India.
Department of Materials Science and Engineering, Yonsei University, Seoul, 03722, South Korea.

R P Dhavale (RP)

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416013, India.

S R Shingte (SR)

Department of Physics, The New College, Shivaji University, Kolhapur, Maharashtra, 416012, India.

P S Patil (PS)

School of Nanoscience and Technology, Shivaji University, Kolhapur, Maharashtra, 416004, India.
Department of Physics, Shivaji University, Kolhapur, Maharashtra, 416004, India.

J H Kim (JH)

Optoelectronic Convergence Research Center and Department of Materials Science and Engineering, Chonnam National University, Gwangju, 500-757, South Korea.

D R T Zahn (DRT)

Semiconductor Physics, Chemnitz University of Technology, 09107, Chemnitz, Germany.

A D Chougale (AD)

Department of Chemistry, The New College, Shivaji University, Kolhapur, Maharashtra, 416012, India.

G Salvan (G)

Semiconductor Physics, Chemnitz University of Technology, 09107, Chemnitz, Germany. salvan@physik.tu-chemnitz.de.

P B Patil (PB)

Department of Physics, The New College, Shivaji University, Kolhapur, Maharashtra, 416012, India. prashantphy@gmail.com.

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