Enhanced Biofilm Eradication and Reduced Cytotoxicity of a Novel Polygalacturonic and Caprylic Acid Wound Ointment Compared with Common Antiseptic Ointments.
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
08
2020
revised:
11
12
2020
accepted:
11
02
2021
entrez:
12
3
2021
pubmed:
13
3
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Antiseptic wound ointments are widely used to treat dermal wounds that are microbially contaminated. Polygalacturonic acid (PG)+caprylic acid (CAP) is a novel combination that has been shown to eradicate biofilms. We developed a novel PG+CAP ointment and compared the biofilm eradication capability and cytotoxicity of PG+CAP with that of commercially available antiseptic wound ointments. We used a well-established biofilm model to quantitatively assess the eradication of organisms following exposure to the wound ointments for 2 hours. PG+CAP ointment completely eradicated
Identifiants
pubmed: 33708989
doi: 10.1155/2021/2710484
pmc: PMC7932769
doi:
Substances chimiques
Anti-Infective Agents, Local
0
Caprylates
0
Ointments
0
Pectins
89NA02M4RX
octanoic acid
OBL58JN025
polygalacturonic acid
VV3XD4CL04
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2710484Informations de copyright
Copyright © 2021 Bahgat Z. Gerges et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest related to this work.
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