behavior
gene dosage
genomic imprinting
hippocampus
neurogenesis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
16 03 2021
16 03 2021
Historique:
entrez:
13
3
2021
pubmed:
14
3
2021
medline:
15
9
2021
Statut:
ppublish
Résumé
Neurogenesis in the adult brain gives rise to functional neurons, which integrate into neuronal circuits and modulate neural plasticity. Sustained neurogenesis throughout life occurs in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus and is hypothesized to be involved in behavioral/cognitive processes such as memory and in diseases. Genomic imprinting is of critical importance to brain development and normal behavior, and exemplifies how epigenetic states regulate genome function and gene dosage. While most genes are expressed from both alleles, imprinted genes are usually expressed from either the maternally or the paternally inherited chromosome. Here, we show that in contrast to its canonical imprinting in nonneurogenic regions,
Identifiants
pubmed: 33712542
pii: 2015505118
doi: 10.1073/pnas.2015505118
pmc: PMC7980393
pii:
doi:
Substances chimiques
Calcium-Binding Proteins
0
Dlk1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 210757/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 21757/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00002X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L002345/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R009791/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R022836/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: G.L. is now an AstraZeneca employee.
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