OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
20
07
2020
accepted:
04
02
2021
revised:
25
01
2021
pubmed:
14
3
2021
medline:
5
3
2022
entrez:
13
3
2021
Statut:
ppublish
Résumé
In bacterial and sterile inflammation of the liver, hepatocyte apoptosis is, in contrast to necroptosis, a common feature. The molecular mechanisms preventing hepatocyte necroptosis and the potential consequences of hepatocyte necroptosis are largely unknown. Apoptosis and necroptosis are critically regulated by the ubiquitination of signaling molecules but especially the regulatory function of deubiquitinating enzymes (DUBs) is imperfectly defined. Here, we addressed the role of the DUB OTU domain aldehyde binding-1 (OTUB1) in hepatocyte cell death upon both infection with the hepatocyte-infecting bacterium Listeria monocytogenes (Lm) and D-Galactosamine (DGal)/Tumor necrosis factor (TNF)-induced sterile inflammation. Combined in vivo and in vitro experiments comprising mice lacking OTUB1 specifically in liver parenchymal cells (OTUB1
Identifiants
pubmed: 33712742
doi: 10.1038/s41418-021-00752-9
pii: 10.1038/s41418-021-00752-9
pmc: PMC8257688
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Ripk1 protein, mouse
EC 2.7.11.1
Ripk3 protein, mouse
EC 2.7.11.1
Cysteine Endopeptidases
EC 3.4.22.-
Otub1 protein, mouse
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2257-2275Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SFB 854
Commentaires et corrections
Type : ErratumIn
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