Thermoregulatory Response to Cold at Various Levels of Activation of Peripheral TRPA1 Ion Channel.
TRPA1 ion channel
allyl isothiocyanate
cold
thermoregulation
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
29
06
2020
pubmed:
14
3
2021
medline:
5
11
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
The effect of TRPA1-ion channel on thermoregulatory responses depending on the level of its activity was studied in Wistar rats. To activate the TRPA1 ion channel localized in the skin, its agonist allyl isothiocyanate (AITC) was used in different concentrations (0.04, 0.4, 1, and 2.5%). Low concentration of AITC (0.04%) enhanced and high concentrations (1 and 2.5%), on the contrary, inhibited cold-defense responses (decreased their magnitude and led to their later initiation due to an increase in temperature thresholds). With an increase in TRPA1 activation, the increase in temperature thresholds (afferent link) was ahead of the decrease in the magnitude of responses (efferent link), which can attest to different sensitivity of these processes to TRPA1 activation.
Identifiants
pubmed: 33713225
doi: 10.1007/s10517-021-05079-6
pii: 10.1007/s10517-021-05079-6
doi:
Substances chimiques
Isothiocyanates
0
TRPA1 Cation Channel
0
Trpa1 protein, rat
0
allyl isothiocyanate
BN34FX42G3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
420-424Références
Almeida MC, Hew-Butler T, Soriano RN, Rao S, Wang W, Wang J, Tamayo N, Oliveira DL, Nucci TB, Aryal P, Garami A, Bautista D, Gavva NR, Romanovsky AA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J. Neurosci. 2012;32(6):2086-2099. doi: https://doi.org/10.1523/JNEUROSCI.5606-11.2012
doi: 10.1523/JNEUROSCI.5606-11.2012
pubmed: 22323721
pmcid: 3566779
Bautista DM, Pellegrino M, Tsunozaki M. TRPA1: A Gatekeeper for Inflammation. Ann. Rev. Physiol. 2013;75:181-200. doi: https://doi.org/10.1146/annurev-physiol-030212-183811
doi: 10.1146/annurev-physiol-030212-183811
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007;448:204-208. doi: https://doi.org/10.1038/nature05910
doi: 10.1038/nature05910
pubmed: 17538622
Brauchi S, Orio P, Latorre R. Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc. Natl Acad. Sci. USA. 2004;101(43):15,494-15,499. doi: https://doi.org/10.1073/pnas.0406773101
doi: 10.1073/pnas.0406773101
Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain. 2011;152(5):1165-1172. doi: https://doi.org/10.1016/j.pain.2011.01.049
doi: 10.1016/j.pain.2011.01.049
pubmed: 21402443
de Oliveira C, Garami A, Lehto SG, Pakai E, Tekus V, Pohoczky K, Youngblood BD, Wang W, Kort ME, Kym PR, Pinter E, Gavva NR, Romanovsky AA. Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J. Neurosci. 2014;34(13):4445-4452. doi: https://doi.org/10.1523/JNEUROSCI.5387-13.2014
doi: 10.1523/JNEUROSCI.5387-13.2014
pubmed: 24671991
pmcid: 3965775
Gavva NR, Davis C, Lehto SG, Rao S, Wang W, Zhu DX. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol. Pain. 2012;8:36. doi: https://doi.org/10.1186/1744-8069-8-36
Kobayashi K, Fukuoka T, Obata K, Yamanaka H, Dai Y, Tokunaga A, Noguchi K. Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J. Comp. Neurol. 2005;493(4):596-606. doi: https://doi.org/10.1002/cne.20794
doi: 10.1002/cne.20794
pubmed: 16304633
Kozyreva TV, Kozaruk VP, Meyta ES. Skin TRPA1 ion channel participates in thermoregulatory response to cold. Comparison with the effect of TRPM8. J Therm Biol. 2019;84:208-213. doi: https://doi.org/10.1016/j.jtherbio.2019.06.010
doi: 10.1016/j.jtherbio.2019.06.010
pubmed: 31466755
Kozyreva TV, Kozaruk VP, Tkachenko EYa, Khramova GM. Agonist of TRPM8 channel, menthol, facilitates the initiation of thermoregulatory responses to external cooling. J. Therm. Biol. 2010;35(8):428-434.
doi: 10.1016/j.jtherbio.2010.09.004
Mammalian Transient Receptor Potential (TRP) Cation Channels. Vol. I. Bernd N, Veit F, eds. Handbook of Experimental Pharmacology. Springer, 2014. Vol. 222. doi: https://doi.org/10.1007/978-3-642-54215-2
Nagata K, Duggan A, Kumar G, García-Añoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J. Neurosci. 2005;25(16):4052-4061. doi: https://doi.org/10.1523/JNEUROSCI.0013-05.2005
doi: 10.1523/JNEUROSCI.0013-05.2005
pubmed: 15843607
pmcid: 6724946
Obata K, Katsura H, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Tominaga M, Noguchi K. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J. Clin. Invest. 2005;115(9):2393-2401. doi: https://doi.org/10.1172/JCI25437
doi: 10.1172/JCI25437
pubmed: 16110328
pmcid: 1187934
Patapoutian A, Peier AM, Story GM, Viswanath V. ThermoTRP channels and beyond: mechanisms of temperature sensation. Nat. Rev. Neurosci. 2003;4(7):529 539. doi: https://doi.org/10.1038/nrn1141
doi: 10.1038/nrn1141
pubmed: 12838328
Raisinghani M, Zhong L, Jeffry JA, Bishnoi M, Pabbidi RM, Pimentel F, Cao DS, Evans MS, Premkumar LS. Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am. J. Physiol. Cell Physiol. 2011;301(3):C587-C600. doi: https://doi.org/10.1152/ajpcell.00465.2010
doi: 10.1152/ajpcell.00465.2010
pubmed: 21653898
pmcid: 3174566