Azathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestations.
Journal
Clinical and experimental dermatology
ISSN: 1365-2230
Titre abrégé: Clin Exp Dermatol
Pays: England
ID NLM: 7606847
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
06
03
2021
received:
16
01
2021
accepted:
11
03
2021
pubmed:
14
3
2021
medline:
23
11
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
Azathioprine is an immunosuppressant drug used in many dermatological and nondermatological pathologies. Azathioprine hypersensitivity syndrome (AHS) is a rare idiosyncratic reaction that is not related to dose or thiopurine methyltransferase activity. Up to half of cases of AHS can present with variable cutaneous manifestations besides fever, malaise and other systemic symptoms. It is important to be aware of AHS, as continuance or reintroduction of the drug can led to multiorgan failure and cardiovascular collapse.
Substances chimiques
Immunosuppressive Agents
0
Azathioprine
MRK240IY2L
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1097-1101Informations de copyright
© 2021 British Association of Dermatologists.
Références
Bidinger JJ, Sky K, Battafarano DF, Henning JS. The cutaneous and systemic manifestations of azathioprine hypersensitivity syndrome. J Am Acad Dermatol 2011; 65: 184-91.
Sinico RA, Sabadini E, Borlandelli S et al. Azathioprine hypersensitivity: report of two cases and review of the literature. J Nephrol 2003; 16: 272-6.
McNally A, Ibbetson J, Sidhu S. Azathioprine-induced Sweet’s syndrome: a case series and review of the literature. Australas J Dermatol 2017; 58: 53-7.
Aleissa M, Nicol P, Godeau M et al. Azathioprine hypersensitivity syndrome: two cases of febrile neutrophilic dermatosis induced by azathioprine. Case Rep Dermatol 2017; 9: 6-11.
Cyrus N, Stavert R, Mason AR et al. Neutrophilic dermatosis after azathioprine exposure. JAMA Dermatol 2013; 149: 592-7.
Bergman SM, Krane NK, Leonard G et al. Azathioprine and hypersensitivity vasculitis. Ann Intern Med 1988; 109: 83-4.
Blanco R, Martínez-Taboada VM, González-Gay MA et al. Acute febrile toxic reaction in patients with refractory rheumatoid arthritis who are receiving combined therapy with methotrexate and azathioprine. Arthritis Rheum 1996; 39: 1016-20.
Beckett CG, Hill P, Hine KR. Leucocytoclastic vasculitis in a patient with azathioprine hypersensitivity. Postgrad Med J 1996; 72: 437-8.
Turow A, Yong TY, Fok JS, Li JYZ. Azathioprine hypersensitivity presenting as cardiogenic shock and Sweet’s syndrome in a patient with microscopic polyangiitis. Intern Med 2012; 51: 1889-92.
Major GA, Moore PG. Profound circulatory collapse due to azathioprine. J R Soc Med 1985; 78: 1052-3.
Jones JJ, Ashworth J. Azathioprine-induced shock in dermatology patients. J Am Acad Dermatol 1993; 29: 795-6.
Cunningham T, Barraclough D, Muirden K. Azathioprine-induced shock. Br Med J (Clin Res Ed) 1981; 283: 823-4.
Yiasemides E, Thom G. Azathioprine hypersensitivity presenting as a neutrophilic dermatosis in a man with ulcerative colitis. Australas J Dermatol 200; 50: 48-51.
Sanchis Sánchez C, Sánchez Motilla JM, Santos Alarcón S et al. Toxicodermia por azatioprina: Utilidad de las pruebas epicutáneas. In: Resúmenes de las comunicaciones de las reuniones del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC). Actas Dermosifiliogr 2016; 107(Esp. Secciones y Grupos de Trabajo): 239-50.Available at: https://www.actasdermo.org/index.php?p=revista&tipo=pdf-simple&pii=X0001731016585473 (accessed 23 March 2021).
Walker GJ, Harrison JW, Heap GA et al. Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease. JAMA 2019; 321: 773-85.
Wang C-H, Chi M-H, Lin J-Y et al. NUDT15 polymorphism identified in a patient with azathioprine hypersensitivity syndrome presenting as erythema nodosum and hepatotoxicity. Br J Dermatol 2019; 181: 631-2.
Chen C-Y, Chiang C-P, Chen H-C et al. Coexisting mutations in CARD14 and NUDT15 detected in a young female with azathioprine hypersensitivity syndrome manifested as acute generalized exanthematous pustulosis. J Dermatol 2020; 47: e109-10.