Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children.
Adolescent
Americas
Asthma
/ epidemiology
Child
Cohort Studies
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
HLA-DQ Antigens
/ metabolism
Humans
Immunoglobulin E
/ metabolism
Indigenous Peoples
Lung
/ immunology
Male
Peru
/ epidemiology
Polymorphism, Single Nucleotide
RNA, Long Noncoding
/ genetics
Spain
Young Adult
Asthma
Peru
admixture
allergy
ancestry
genome wide association analyses
immunoglobulin E
lung function
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
08
06
2020
revised:
20
02
2021
accepted:
24
02
2021
pubmed:
14
3
2021
medline:
22
12
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
Genetic ancestry plays a role in asthma health disparities. Our aim was to evaluate the impact of ancestry on and identify genetic variants associated with asthma, total serum IgE level, and lung function. A total of 436 Peruvian children (aged 9-19 years) with asthma and 291 without asthma were genotyped by using the Illumina Multi-Ethnic Global Array. Genome-wide proportions of indigenous ancestry populations from continental America (NAT) and European ancestry from the Iberian populations in Spain (IBS) were estimated by using ADMIXTURE. We assessed the relationship between ancestry and the phenotypes and performed a genome-wide association study. The mean ancestry proportions were 84.7% NAT (case patients, 84.2%; controls, 85.4%) and 15.3% IBS (15.8%; 14.6%). With adjustment for asthma, NAT was associated with higher total serum IgE levels (P < .001) and IBS was associated with lower total serum IgE levels (P < .001). NAT was associated with higher FEV This study confirms the role of HLA in atopy, and identifies a novel locus mapping to a long noncoding RNA for lung function that may be specific to children with NAT.
Sections du résumé
BACKGROUND
Genetic ancestry plays a role in asthma health disparities.
OBJECTIVE
Our aim was to evaluate the impact of ancestry on and identify genetic variants associated with asthma, total serum IgE level, and lung function.
METHODS
A total of 436 Peruvian children (aged 9-19 years) with asthma and 291 without asthma were genotyped by using the Illumina Multi-Ethnic Global Array. Genome-wide proportions of indigenous ancestry populations from continental America (NAT) and European ancestry from the Iberian populations in Spain (IBS) were estimated by using ADMIXTURE. We assessed the relationship between ancestry and the phenotypes and performed a genome-wide association study.
RESULTS
The mean ancestry proportions were 84.7% NAT (case patients, 84.2%; controls, 85.4%) and 15.3% IBS (15.8%; 14.6%). With adjustment for asthma, NAT was associated with higher total serum IgE levels (P < .001) and IBS was associated with lower total serum IgE levels (P < .001). NAT was associated with higher FEV
CONCLUSION
This study confirms the role of HLA in atopy, and identifies a novel locus mapping to a long noncoding RNA for lung function that may be specific to children with NAT.
Identifiants
pubmed: 33713768
pii: S0091-6749(21)00366-3
doi: 10.1016/j.jaci.2021.02.035
pmc: PMC8429514
mid: NIHMS1694170
pii:
doi:
Substances chimiques
HLA-DQ Antigens
0
RNA, Long Noncoding
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1493-1504Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES018845
Pays : United States
Organisme : FIC NIH HHS
ID : R25 TW009340
Pays : United States
Organisme : NIMHD NIH HHS
ID : K99 MD015767
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007007
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142992
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL096955
Pays : United States
Informations de copyright
Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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