Cerebrospinal fluid from frontotemporal dementia patients is toxic to neurons.
Cerebrospinal fluid
Cytotoxicity
Frontotemporal dementia
Neuronal cell culture
Synaptic activity
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
21
01
2021
revised:
02
03
2021
accepted:
04
03
2021
pubmed:
14
3
2021
medline:
11
9
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
Frontotemporal Lobar Degeneration (FTD) is a neurodegenerative disease characterized by a progressive deterioration of cognitive functions. Currently, no effective treatment exists. We have studied cytotoxicity and neuronal functionality in cortical and spinal cord cultures upon exposure to cerebrospinal fluid (CSF) from 39 FTD patients. FTD-CSF alters the miniature excitatory postsynaptic currents in the cortical cultures and it is toxic to spinal cord cultures, particularly to GABAergic+ and calbindin-D28k + neurons.
Identifiants
pubmed: 33713790
pii: S0925-4439(21)00055-7
doi: 10.1016/j.bbadis.2021.166122
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
166122Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.