Glycan structure-based perspectives on the entry and release of glycoproteins in the calnexin/calreticulin cycle.

Calnexin / chemistry Calreticulin / chemistry Carbohydrate Conformation Glycoproteins / chemistry Polysaccharides / chemistry
Calnexin/calreticulin cycle Chemical approach Glucosidase Mannosidase Monoglucosylated oligomannose-type glycan

Journal

Carbohydrate research
ISSN: 1873-426X
Titre abrégé: Carbohydr Res
Pays: Netherlands
ID NLM: 0043535

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 31 12 2020
revised: 16 02 2021
accepted: 23 02 2021
pubmed: 14 3 2021
medline: 28 10 2021
entrez: 13 3 2021
Statut: ppublish

Résumé

N-glycans are attached to newly synthesised polypeptides and are involved in the folding, secretion, and degradation of N-linked glycoproteins. In particular, the calnexin/calreticulin cycle, which is the central mechanism of the entry and release of N-linked glycoproteins depending on the folding sates, has been well studied. In addition to biological studies on the calnexin/calreticulin cycle, several studies have revealed complementary roles of in vitro chemistry-based research in the structure-based understanding of the cycle. In this mini-review, we summarise chemistry-based results and highlight their importance for further understanding of the cycle.

Identifiants

DOI: 10.1016/j.carres.2021.108273 PMID: 33713911
pubmed: 33713911
pii: S0008-6215(21)00042-2
doi: 10.1016/j.carres.2021.108273
pii:
doi:

Substances chimiques

Calreticulin 0
Glycoproteins 0
Polysaccharides 0
Calnexin 139873-08-8

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

108273

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Taiki Kuribara (T)

Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-kitamachiMusashino-shi, Tokyo, 180-8633, Japan.

Ruchio Usui (R)

Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-kitamachiMusashino-shi, Tokyo, 180-8633, Japan.

Kiichiro Totani (K)

Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-kitamachiMusashino-shi, Tokyo, 180-8633, Japan. Electronic address: ktotani@st.seikei.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Calnexine › Glycan structure-based perspectives on the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Calréticuline › Glycan structure-based perspectives on the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des glucides › Glycan structure-based perspectives on the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Glycan structure-based perspectives on the...
questionsmedicales.fr › Glucides › Polyosides › Glycan structure-based perspectives on the...