CDH6-activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers.
CDH6
metastasis
ovarian and renal cancer
platelets
α2β1 integrin
αIIbβ3 integrin
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
25
01
2021
received:
14
09
2020
accepted:
12
03
2021
pubmed:
15
3
2021
medline:
8
4
2022
entrez:
14
3
2021
Statut:
ppublish
Résumé
Cadherin 6 (CDH6) is significantly overexpressed in advanced ovarian and renal cancers. However, the role of CDH6 in cancer metastasis is largely unclear. Here, we investigated the impact of CDH6 expression on integrin-mediated metastatic progression. CDH6 preferentially bound to αIIbβ3 integrin, a platelet receptor scarcely expressed in cancer cells, and this interaction was mediated through the cadherin Arginine-glycine-aspartic acid (RGD) motif. Furthermore, CDH6 and CDH17 were found to interact with α2β1 in αIIbβ3
Identifiants
pubmed: 33715292
doi: 10.1002/1878-0261.12947
pmc: PMC8253092
doi:
Substances chimiques
Cadherins
0
Integrin alpha2beta1
0
Platelet Glycoprotein GPIIb-IIIa Complex
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1849-1865Informations de copyright
© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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