The impact of mitochondria-related
Adult
Aged
Alleles
Breast Neoplasms
/ genetics
DNA Polymerase gamma
/ genetics
DNA-Binding Proteins
/ genetics
Female
Gene Frequency
Genetic Predisposition to Disease
/ genetics
Genotype
Humans
Kaplan-Meier Estimate
Logistic Models
Middle Aged
Mitochondria
/ genetics
Mitochondrial Proteins
/ genetics
Neoplasm Recurrence, Local
Polymorphism, Single Nucleotide
Transcription Factors
/ genetics
POLG
SNV
TFAM
breast cancer
outcome
tumour phenotype
Journal
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
ISSN: 1366-5804
Titre abrégé: Biomarkers
Pays: England
ID NLM: 9606000
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
16
3
2021
medline:
27
11
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
Breast cancer is the most frequent female cancer, leading to relapse with distant metastasis of approximately one-third of patients. Cancer is usually considered a genetic disease involving mutations in nuclear DNA. However, genes, coding for mitochondrial proteins or regulatory molecules, are rarely under consideration. This study aimed to analyse 10 single nucleotide variants in A total of 234 breast cancer patients were included in this study. Variations were determined with Real-Time PCR using TaqMan We found that patients with Our data suggest that variations in
Identifiants
pubmed: 33715547
doi: 10.1080/1354750X.2021.1900397
doi:
Substances chimiques
DNA-Binding Proteins
0
Mitochondrial Proteins
0
TFAM protein, human
0
Transcription Factors
0
DNA Polymerase gamma
EC 2.7.7.7
POLG protein, human
EC 2.7.7.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM