Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1.
Animals
Antineoplastic Agents
/ pharmacology
Bortezomib
/ pharmacology
CD8-Positive T-Lymphocytes
/ drug effects
Cell Line, Tumor
Cytokines
/ metabolism
Disease Models, Animal
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Lymphocyte Count
Mice
MicroRNAs
/ chemistry
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
/ chemistry
Proteasome Inhibitors
/ pharmacology
RNA Folding
RNA Interference
Signal Transduction
Suppressor of Cytokine Signaling 1 Protein
/ chemistry
T cell exhaustion
antitumor immunity
cancer immunotherapy
immunomodulators
immunosuppression
lymphocyte function
microRNA
tumor microenvironment
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
09
2020
accepted:
07
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Suppressive mechanisms operating within T cells are linked to immune dysfunction in the tumor microenvironment. We have previously reported using adoptive T cell immunotherapy models that tumor-bearing mice treated with a regimen of proteasome inhibitor, bortezomib - a dipeptidyl boronate, show increased antitumor lymphocyte effector function and survival. Here, we identify a mechanism for the improved antitumor CD8
Identifiants
pubmed: 33717088
doi: 10.3389/fimmu.2021.607044
pmc: PMC7946819
doi:
Substances chimiques
Antineoplastic Agents
0
Cytokines
0
MicroRNAs
0
Mirn155 microRNA, mouse
0
Proteasome Inhibitors
0
Socs1 protein, mouse
0
Suppressor of Cytokine Signaling 1 Protein
0
Bortezomib
69G8BD63PP
Inpp5d protein, mouse
EC 3.1.3.86
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
EC 3.1.3.86
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
607044Subventions
Organisme : NIAID NIH HHS
ID : R56 AI122960
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA163069
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042348
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA175370
Pays : United States
Organisme : NIDA NIH HHS
ID : R24 DA036420
Pays : United States
Organisme : NCI NIH HHS
ID : SC1 CA182843
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136740
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007737
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007593
Pays : United States
Informations de copyright
Copyright © 2021 Renrick, Thounaojam, de Aquino, Chaudhuri, Pandhare, Dash and Shanker.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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