Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model.
Animals
Anti-Asthmatic Agents
/ pharmacology
Asthma
/ genetics
Bronchoconstriction
/ drug effects
Case-Control Studies
Child
Cytokines
/ metabolism
DNA Copy Number Variations
Disease Models, Animal
Female
Gene Dosage
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Hypersensitivity
/ genetics
Inflammation Mediators
/ metabolism
Lung
/ drug effects
Male
Mice, Inbred BALB C
Mutation
Phenotype
Polymorphism, Single Nucleotide
beta-Defensins
/ genetics
asthma
atopy
defensin
hBD-2
prevention
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
11
2020
accepted:
14
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
21
9
2021
Statut:
epublish
Résumé
Asthma and allergies are complex, chronic inflammatory diseases in which genetic and environmental factors are crucial. Protection against asthma and allergy development in the context of farming environment is established by early animal contact, unpasteurized milk consumption and gut microbiota maturation. The human β-defensin 2 (hBD-2) is a host defense peptide present almost exclusively in epithelial tissues, with pronounced immunomodulatory properties, which has recently been shown to ameliorate asthma and IBD in animal models. We hypothesized that adequate hBD-2 secretion plays a role in the protection against asthma and allergy development and that genetic variations in the complex gene locus coding for hBD-2 may be a risk factor for developing these diseases, if as a consequence, hBD-2 is insufficiently produced. We used MALDI-TOF MS genotyping, sequencing and a RFLP assay to study the genetic variation including mutations, polymorphisms and copy number variations in the locus harboring both genes coding for hBD-2 (
Identifiants
pubmed: 33717182
doi: 10.3389/fimmu.2021.636061
pmc: PMC7946850
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Cytokines
0
DEFB4A protein, human
0
Inflammation Mediators
0
beta-Defensins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
636061Informations de copyright
Copyright © 2021 Borchers, Santos-Valente, Toncheva, Wehkamp, Franke, Gaertner, Nordkild, Genuneit, Jensen and Kabesch.
Déclaration de conflit d'intérêts
PN is employed by Defensin Therapeutics. PN and JW hold shares of Defensin Therapeutics. Defensin Therapeutics holds patents on treatment with defensins. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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